MACULA DENSA DEVELOPMENT

黄斑致密区发育

• 批准号: 2136406
• 负责人: LOIS J AREND
• 金额: $ 3.53万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-02-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2136406
• 关键词: MACULA; DENSA; DEVELOPMENT

The aim of the proposed work is to better understand the development of the juxtaglomerular apparatus (JGA), in particular, the macula densa. The macula densa is a specialized portion of the distal tubule and is a key feature of the JGA, as it is believed to signal the other components of the JGA regarding distal tubule fluid composition, effecting changes in renal blood flow, glomerular filtration, and renin release. Relatively little is known about the development of this important region of the kidney. By identifying specific markers that can be used to delineate the macula densa, and applying this information to fetal kidneys, the development of this specialized portion of the nephron can be better characterized. Identification of the macula densa cells will also aid in studies aimed at uncovering the lineage, and, eventually, the isolation and in vitro study of these intriguing cells. Since the JGA is involved in control of the renin-angiotensin system and glomerular function, a better characterization of its development may be useful in understanding the basis for renal-based systemic diseases such as hypertension as well as diseases intrinsic to the kidney.

拟议工作的目的是更好地了解 近齿腔（JGA），尤其是黄斑densa。这 黄斑densa是远端小管的专业部分，是钥匙 JGA的特征，因为据信它会发出其他组件的信号 关于远端小管液组成的JGA，影响 肾血流，肾小球过滤和肾素释放。相对地 关于这个重要地区的发展知之甚少 肾。通过确定可用于描述的特定标记 黄斑densa，并将这些信息应用于胎儿肾脏， 开发肾单位的专业部分可能会更好 特征。黄斑densa细胞的识别也将有助于 旨在发现谱系的研究，并最终是隔离 并在体外研究这些有趣的细胞。由于JGA涉及 在控制肾素 - 血管紧张素系统和肾小球功能时， 更好地表征其发展可能有助于理解 基于肾脏的全身性疾病（例如高血压）的基础 随着肾脏固有的疾病。