A ‘healthy’ processed food to normalise and maintain blood sugar levels in individuals at risk of Type-II Diabetes

一种“健康”的加工食品，可使有 II 型糖尿病风险的个体的血糖水平正常化并保持正常水平

• 批准号: 105129
• 金额: $ 45.74万
• 依托单位: THE SMARTER FOOD COMPANY LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=105129
• 关键词: healthy; processed; food; normalise; maintain

This project will secure critical data for a dietary intervention to reduce fasting blood glucose (FBG) levels in people who are defined as being 'pre-diabetic'. A simple dietary solution of this nature has the potential to have a significant impact on the incidence of type-II diabetes (T2D), a major and growing problem in UK and throughout the world: it is estimated that there are 15m pre-diabetic people in the UK and 4m with T2D and globally over 1bn pre- diabetic and 370m diabetic. Diabetes prescriptions alone cost the NHS over £1bn every year. Therefore, this project addresses a public health issue of great importance, and for which there are large and growing market opportunities.Data from a two-year study on diet and prostate cancer with our proprietary soup product showed that individuals had a reduction in their higher-than- normal blood glucose to levels associated with good health, and remained at this lower level for the duration of the trial. This effect was achieved by consuming just one 300ml portion of soup per week, with no other changes to diet or lifestyle. Blood glucose reduction was not the primary endpoint of this study, and a larger study is needed that is specially focussed on the effect of our food product on blood glucose.The Smarter Food Company (TSFC) has been established to develop this technology and bring to market food products that will assist in the management of blood glucose. TSFC is seeking UKI2S Accelerator funding, matched by private investment, to undertake a human trial of a critical size, and design, to test the hypothesis that a single portion of soup will reduce blood glucose in pre-diabetic individuals to 'healthy' levels. The soup is manufactured from a unique and proprietary broccoli naturally bred to contain very high concentrations of glucoraphanin (VHG). This soup will be used to validate the original findings and confirm the role of glucoraphanin in delivering the desired effect. The successful outcome of the trial will lever substantial private investment to bring this product to market as well as future products. These foods will be marketed to pre-diabetics, health care professionals involved with screening, monitoring and treating T2D, diabetes charities and other relevant NGOs, the health-conscious and worried well, with an approved European Food Standards Agency (EFSA) health claim, and equivalent for other markets. The products will be sold through the major food retailers and by direct online sales.

该项目将确保饮食干预的关键数据，以降低被定义为糖尿病前期的人的空腹血糖(FBG)水平。这种性质的简单饮食解决方案可能会对II型糖尿病(T2D)的发病率产生重大影响，T2D是英国和世界各地日益严重的一个主要问题：据估计，英国有1500万糖尿病前期患者，400万T2D患者，全球超过10亿糖尿病前期患者和3.7亿糖尿病患者。仅糖尿病处方一项，NHS每年就要花费超过10亿英镑。因此，这个项目解决了一个非常重要的公共健康问题，对此有巨大的和不断增长的市场机会。我们的专利汤产品对饮食和前列腺癌进行了为期两年的研究，数据显示，个人的血糖水平高于正常水平，降至与健康相关的水平，并在试验期间保持在较低水平。这种效果是通过每周只喝一份300毫升的汤来实现的，饮食或生活方式没有其他变化。降低血糖并不是这项研究的主要终点，需要进行更大规模的研究，专门关注我们的食品对血糖的影响。为了开发这项技术，并将有助于血糖管理的食品推向市场，已经成立了Smarter Food Company(TSFC)。TSFC正在寻求UKI2S加速器的资金，并辅之以私人投资，进行一项关键规模的人体试验，并设计测试一份汤就能将糖尿病前期患者的血糖降低到“健康”水平的假设。这种汤是由一种独特的专有西兰花制成的，天然培养的西兰花含有非常高浓度的葡萄糖萝卜素(VHG)。这道汤将被用来验证最初的发现，并确认葡萄糖萝卜素在实现预期效果方面的作用。试验的成功结果将拉动大量的私人投资，将这种产品以及未来的产品推向市场。这些食品将销售给糖尿病前期患者、从事T2D筛查、监测和治疗的医疗保健专业人员、糖尿病慈善机构和其他相关非政府组织、具有健康意识和担忧的人、具有欧洲食品标准局(EFSA)批准的健康声明的人，以及面向其他市场的同等产品。这些产品将通过主要的食品零售商和在线直销销售。