Health Behaviors and Mortality in Prostate Cancer Survivors in the Multiethnic Cohort Study
多种族队列研究中前列腺癌幸存者的健康行为和死亡率
基本信息
- 批准号:10512554
- 负责人:
- 金额:$ 8.08万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-23 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAfrican AmericanAmericanAmerican Association of Cancer ResearchAnimal FeedAsian AmericansAsian Pacific AmericanBaseline SurveysBehaviorBlack raceBody SizeBody WeightBody mass indexCaliforniaCancer SurvivorCenters for Disease Control and Prevention (U.S.)Cessation of lifeChineseClinicalCoffeeCohort StudiesCox Proportional Hazards ModelsDataDiabetes MellitusDiagnosisDiagnosticDietDietary ComponentDietary FactorsDietary FiberEdible PlantsEnrollmentEnsureEthnic OriginEthnic groupFabaceaeFamilyFamily CaregiverFoodFrequenciesFundingHealth behaviorHeart DiseasesHispanicIncidenceInstitutesIntakeInterventionJapaneseKnowledgeLatinoLatinxLatinx populationMalignant neoplasm of prostateMeasuresMeatMediatingMedicalNative HawaiianNonmetastaticNutsOutcomePacific Island AmericansParticipantPatientsPersonsPharmaceutical PreparationsPhysical activityPhysiciansPlantsPopulationPopulation HeterogeneityProcessed MeatsProgress ReportsProspective StudiesProstatePublic HealthQuestionnairesRaceRecommendationRecording of previous eventsReportingResearchRiskRisk FactorsSelf AdministrationSmokingSmoking HistorySurveysTeaUnited StatesUpdateVascular PlantVegetable OilsVegetablesWeightWorkadvanced diseaseanticancer researchbasecancer diagnosiscancer health disparitycancer riskcohortdemographicsdietaryeggethnic diversityfollow-upfruits and vegetableshealthy lifestylehigh riskimprovedindexinginterestmenmodifiable riskmortalitymortality riskmulti-ethnicpopulation basedprimary outcomeprostate cancer riskprostate cancer survivorsracial and ethnicracial and ethnic disparitiesresearch studysaturated fatsecondary outcometumor progression
项目摘要
PROJECT ABSTRACT:
Large racial/ethnic disparities exist for prostate cancer (PC) incidence and mortality. Between 2001-2017, the
5-year relative survival for Black, Asian American/Pacific Islander, and Latinx groups was lower compared to
non-Latinx White men. Progressing to advanced disease is a pivotal concern among patients with non-
metastatic PC, their family, caregivers, and physicians. A major gap in current knowledge is the lack of
research studies focused on post-diagnostic modifiable factors from racially/ethnically diverse populations.
Preliminary data suggest that a Healthful Plant-based Diet Index may be associated with a ~60% lower risk of
incident fatal PC among healthy men. In addition, our team recently developed a post-diagnostic Prostate
Health Behavior Score (focused on physical activity, weight, and diet) with higher scores associated with a
~55% lower risk of PC-specific mortality among men with PC. Even so, 92% of participants in these two
analyses identified as non-Latinx White; thus, the findings may not be generalizable to the racially/ethnically
diverse populations of people living with PC. In this R03, we propose to examine whether a Healthful Plant-
based Diet Index or composite Prostate Health Behavior Score is associated with survival among men with PC
in the population-based Multiethnic Cohort Study (MEC). The MEC is a diverse cohort of over 215,000 adults
living predominately in southern California and Hawai’i when enrolled between 1993-1996. For these analyses,
we will use data from 2,652 men with PC who have measures of health behaviors before and after diagnosis;
19% identified as African American, 25% identified as non-Latino White, 23% identified as Latino, 28%
identified as Asian American, and 5% identified as Native Hawaiian. A comprehensive self-administered
questionnaire captured demographics, body size, medical and family histories, medication use, smoking
history, and physical activity at enrollment; and a quantitative food frequency questionnaire (FFQ) was also
administered. Follow-up surveys have been administered every 4-6 years. Data from the baseline survey will
be used to adjust for pre-diagnosis health behaviors and body weight. Using these data, we aim to 1) examine
whether the Healthful Plant-based Diet Index, a Prostate Health Behavior Score, and their components,
measured after PC diagnosis, are associated with lower risk of all-cause and PC-specific mortality; and 2)
explore whether associations between these modifiable risk factors and mortality vary across racial/ethnic
groups and the degree to which health behaviors contribute to observed racial/ethnic disparities in PC
mortality. This work will be completed in the largest prospective study of racially/ethnically diverse men with PC
in the U.S., ensuring the generalizability of our results and directly informing clinical and public health
recommendations. In addition, this proposal will strengthen the evidence on the impact of health behaviors on
outcomes in cancer survivors and could help reduce racial/ethnic disparities in PC outcomes, and guide
interventions to ultimately help people with PC lower their risk of cancer progression and death.
项目简介:
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Stacey Kenfield其他文献
Stacey Kenfield的其他文献
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{{ truncateString('Stacey Kenfield', 18)}}的其他基金
Health Behaviors and Mortality in Prostate Cancer Survivors in the Multiethnic Cohort Study
多种族队列研究中前列腺癌幸存者的健康行为和死亡率
- 批准号:
10709584 - 财政年份:2022
- 资助金额:
$ 8.08万 - 项目类别:
Impact of Web-Based Lifestyle Interventions on Prostate Cancer Prognosis
基于网络的生活方式干预对前列腺癌预后的影响
- 批准号:
9534558 - 财政年份:2016
- 资助金额:
$ 8.08万 - 项目类别:
Impact of Web-Based Lifestyle Interventions on Prostate Cancer Prognosis
基于网络的生活方式干预对前列腺癌预后的影响
- 批准号:
9982038 - 财政年份:2016
- 资助金额:
$ 8.08万 - 项目类别:
Impact of Web-Based Lifestyle Interventions on Prostate Cancer Prognosis
基于网络的生活方式干预对前列腺癌预后的影响
- 批准号:
10225353 - 财政年份:2016
- 资助金额:
$ 8.08万 - 项目类别:
Impact of Web-Based Lifestyle Interventions on Prostate Cancer Prognosis
基于网络的生活方式干预对前列腺癌预后的影响
- 批准号:
9319234 - 财政年份:2016
- 资助金额:
$ 8.08万 - 项目类别:
Impact of Web-Based Lifestyle Interventions on Prostate Cancer Prognosis
基于网络的生活方式干预对前列腺癌预后的影响
- 批准号:
9157789 - 财政年份:2016
- 资助金额:
$ 8.08万 - 项目类别:
A Randomized Clinical Trial of Exercise for Men with Metastatic Prostate Cancer
对患有转移性前列腺癌的男性进行运动的随机临床试验
- 批准号:
8892916 - 财政年份:2015
- 资助金额:
$ 8.08万 - 项目类别:
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