DEVICE FOR IN VIVO DELIVERY OF NITRIC OXIDE

用于体内输送一氧化氮的装置

• 批准号: 2253013
• 负责人: HARRY FEIN
• 金额: $ 7.95万
• 依托单位: WORLD PRECISION INSTRUMENTS, INC.
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 1995-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2253013
• 关键词: biological models; cats; drug delivery systems; drug design /synthesis /production; drug screening /evaluation; nitric oxide; photostimulus

DESCRIPTION: (Adapted from Applicant's Abstract) Nitric oxide (NO) is a free-radical gas that is implicated in many important physiological roles, including such fundamental processes as blood pressure regulation and memory formation. While much indirect research has been performed on systems that use NO, studies of direct in vivo application of NO have been hindered by the volatility of NO and the potential toxicity of currently-used methods of delivering it. A new method for delivering NO is proposed, based on the availability of new, "caged" compounds. These substances conserve their biological activity until activated with light stimuli of the appropriate wavelength. A sequential, three stage experimental approach will be employed to prove the feasibility of the method, culminating in the demonstration of feasibility in an experimental animal model. In addition to enabling NO delivery in an animal with intact neuronal and vascular circuits, the method will apply to other neurotransmitters. Based on the design flexibility, a wide range of potential applications are envisioned: in micropharmacology experiments (where the delivery method promises better temporal resolution and receptor coverage than currently available micropharmacological techniques, including microiontophoresis and pressure ejection); in new in vivo and in vitro macropharmacological approaches; and in new photodynamic cancer therapies.

描述：（改编自申请人摘要）一氧化氮（NO）是

项目成果

Photolytic generation of nitric oxide through a porous glass partitioning membrane.

通过多孔玻璃隔离膜光解产生一氧化氮。

• DOI: 10.1006/niox.1998.0195
• 发表时间: 1998
• 期刊: Nitric oxide : biology and chemistry
• 作者: Zhelyaskov,VR;Godwin,DW
• 通讯作者: Godwin,DW

A nitric oxide concentration clamp.

• DOI: 10.1006/niox.1999.0253
• 发表时间: 1999-10
• 期刊: Nitric oxide : biology and chemistry
• 作者: V. Zhelyaskov;D. Godwin

Control of NO Concentration in Solutions of Nitrosothiol Compounds by Light

光控制亚硝基硫醇化合物溶液中 NO 浓度

• DOI: 10.1111/j.1751-1097.1998.tb05200.x
• 发表时间: 1998
• 期刊: Photochemistry and Photobiology
• 影响因子: 3.3
• 作者: V. Zhelyaskov;K. Gee;D. Godwin
• 通讯作者: D. Godwin