LIPOPHILIC CALCIUM FLUOROIONOPHORES

亲脂性钙氟离子载体

• 批准号: 2188566
• 负责人: MARGARET E LANGMUIR
• 金额: $ 7.5万
• 依托单位: COVALENT ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-12-01 至 1994-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2188566
• 关键词: alpha benzopyrone; biosensor device; body fluids; calcium flux; chemical synthesis; fiber optics; fluorescence; high performance liquid chromatography; hydropathy; ionophores; membrane reconstitution /synthesis; water solution

We propose to synthesize and test new lipophilic fluorescent ionophores for measuring calcium ion concentrations in aqueous solutions. The ionophores are designed to be soluble in synthetic membranes and to respond selectively to Ca2+ in a contacting aqueous solution by undergoing a shift in absorption and emission to longer wavelengths. The proposed compounds will be of primary interest for incorporating into a fiber optic chemical sensor (FOCS). A FOCS device will be of use for determining the concentration of calcium ion in biological fluids in vitro and ultimately in vivo. A device based on this design would be valuable in the intensive care unit or other hospital facility.

我们建议合成和测试新的亲脂性荧光离子载体 用于测量水溶液中的钙离子浓度。的 离子载体被设计成可溶于合成膜， 选择性地响应于接触水溶液中的Ca2+， 吸收和发射向更长波长的转变。拟议 化合物将主要用于结合到光纤中 化学传感器（FOCS）。FOCS设备将用于确定 体外生物体液中钙离子的浓度， in vivo.基于这种设计的设备在密集型应用中是有价值的。 护理单位或其他医院设施。