Molecular basis for susceptibility and immunity to Fusarium wilt disease

对枯萎病的易感性和免疫性的分子基础

• 批准号: DP200100388
• 负责人: Prof David Jones
• 金额: $ 25.28万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-03-17 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200100388
• 关键词: Molecular; basis; susceptibility; immunity; Fusarium

Fusarium wilt is a devastating disease of many important crop plants, including banana, cotton and tomato. There are significant gaps in our understanding of this disease that need to be addressed to enable better disease management. This project aims to identify and analyse tomato proteins targeted by Fusarium effector proteins (virulence factors), determine how corresponding tomato receptors (resistance proteins) recognise these effectors, and identify the signalling pathways and critical defence responses activated by these receptors. The intention is to close the gaps in our understanding and use the knowledge gained to develop new strategies for disease control by interfering with fungal pathogenicity and enhancing plant resistance.

枯萎病是一种危害香蕉、棉花、番茄等重要作物的毁灭性病害。我们对这一疾病的认识存在重大差距，需要加以解决，以便能够更好地进行疾病管理。该项目旨在鉴定和分析镰刀菌效应蛋白（毒力因子）靶向的番茄蛋白，确定相应的番茄受体（抗性蛋白）如何识别这些效应子，并鉴定这些受体激活的信号通路和关键防御反应。其目的是缩小我们的理解差距，并利用所获得的知识，通过干扰真菌致病性和增强植物抗性来开发疾病控制的新策略。