Acquisition of the mitochondrial genome restores mitochondrial function

获取线粒体基因组可恢复线粒体功能

• 批准号: DP150102820
• 负责人: Prof Jiri Neuzil
• 金额: $ 26.63万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150102820
• 关键词: Acquisition; mitochondrial; genome; restores; function

The aim of this project is to show that cancer cells with heavily damaged mitochondrial DNA (mtDNA) can acquire the mitochondrial genome from the host and that this results in the recovery of their mitochondrial function. The project is highly significant, as it aims to show in vivo mitochondrial transfer with functional consequences. The project aims to open a new avenue of research and could result in a shift in our understanding of some features of cellular communication and how cells can overcome unfavourable situations.

该项目的目的是证明线粒体DNA（mtDNA）严重受损的癌细胞可以从宿主中获得线粒体基因组，这导致其线粒体功能的恢复。该项目是非常重要的，因为它的目的是显示在体内线粒体转移功能的后果。该项目旨在开辟一条新的研究途径，并可能导致我们对蜂窝通信的某些特征以及细胞如何克服不利情况的理解发生转变。