TIME RELATED FACTORS IN RADIATION CANCER DOSE RESPONSE

辐射癌剂量反应中的时间相关因素

• 批准号: 2277973
• 负责人: Steven B Wing
• 金额: $ 2.83万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-07-01 至 1997-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2277973
• 关键词: human mortality; human subject; ionizing radiation; mathematical model; neoplasm /cancer epidemiology; occupational disease /disorder; occupational hazard; radiation carcinogenesis; radiation hazard; radiation related neoplasm /cancer

The overall objective of this study is to contribute to the understanding of the association between chronic occupational exposure to low dose, penetrating ionizing radiation and cancer mortality. The cohort of workers employed at Oak Ridge National Laboratory provides a valuable resource for studying radiation health effects; however, inconsistent estimates of the radiation-cancer dose-response relationship reported in previous studies of this cohort suggest the need to further examine time- related confounders and effect modifiers. The proposed study will describe relationships between low dose radiation and mortality using an expanded cohort of ORNL workers, extended mortality follow-up, including workers with employment at other DOE facilities, and recently revised estimates of radiation exposure. In evaluating radiation-cancer dose- response relationships in this updated cohort, analyses will consider time-related confounders and effect modifiers which have been suggested by previous occupational studies. These time-related factors include time patterns in radiation exposure and covariates, selection in and out of employment, changes over time in the quality of exposure measurement, contribution of age at exposure, exposure lag, and time since exposure. Recently developed analytical methods for studying induction time will allow investigation of potentially critical time windows of exposure. Modification of the dose-response pattern by age at exposure will be also investigated. Finally, evidence for residual confounding will be sought by considering the association between radiation and non-cancer mortality. This study will provide new epidemiological data about low dose radiation health effects from one of the best available data sources. Furthermore, the analyses of induction time and modification by age at exposure will provide new insights into the radiation-cancer relationship, and expand the methodological literature on time-related factors in occupational epidemiology. Finally, the public concern about low dose radiation, and the prevalence of the exposure make this study a valuable service for addressing these public concerns.

本研究的总体目标是帮助理解 慢性职业性低剂量暴露之间的联系， 穿透性电离辐射和癌症死亡率。 队列 橡树岭国家实验室的工作人员提供了一个有价值的 研究辐射健康影响的资源;然而，不一致的 报告的辐射-癌症剂量-反应关系的估计数 以前对这一群体的研究表明，需要进一步研究时间- 相关混杂因素和效应修饰因子。 拟定的研究将 描述低剂量辐射与死亡率之间的关系， 扩大ORNL工作者队列，延长死亡率随访，包括 在其他能源部设施就业的工人，最近修订 辐射暴露的估计。 在评估辐射-癌症剂量- 在该更新队列中，分析将考虑 时间相关的混杂因素和效应修饰因子， 以前的职业研究。 这些与时间相关的因素包括时间 辐射暴露和协变量的模式， 就业、暴露测量质量随时间的变化， 暴露时年龄、暴露滞后和暴露后时间的贡献。 最近开发的研究感应时间的分析方法将 允许调查潜在的关键暴露时间窗口。 还将根据暴露时的年龄修改剂量-反应模式， 研究了 最后，将寻找剩余混杂因素的证据 通过考虑辐射和非癌症死亡率之间的联系。 这项研究将提供有关低剂量辐射的新的流行病学数据 健康影响的最佳数据来源之一。 此外，委员会认为， 对诱导时间和暴露时年龄变化的分析将 为辐射与癌症的关系提供新的见解，并扩大 职业性疾病时间相关因素的方法学文献 流行病学 最后，公众对低剂量辐射的关注， 暴露的普遍性使这项研究成为一项有价值的服务， 解决这些公众关注。