10 ELECTRON ELECTROPHILIC FLUORINATING AGENTS

有机氟化合物广泛用作化学治疗剂。更 最近，18F标记的化合物在正电子发射中变得重要 断层扫描虽然各种氟化剂和氟化 已知的方法很少有已知的引入氟的方法 进入富电子系统，如烯烃、芳烃等。 绝大多数氟化剂是亲核的。由于氟是 已知的电负性最强的元素， 亲电氟化试剂是可获得的。我们建议，作为 一个FIRCA基金，准备和研究10电子等电子 硒（II）、硒（IV）、碲（IV）和铋（V）作为“功率可变亲电性 氟化剂”。所提出的化学类似于 碘（III）的使用正在经历一场复兴。具体来说，ArSeF3， 将研究ArTeF 3和Ar3 BiF 2沿着与XeF2作为氟化剂 用于烯烃的试剂。同样地，FXeOSO2F、FXeOSO2CF3和CF3（OSO2F）2， 将研究NH4（OSO2CF3）2作为亲电引入的手段 这些氟磺酸酯基团转化为烯烃。生物活性 诸如氟类固醇的化合物将与其它化合物一起沿着制备 医药上有用的含氟化合物。

Organo-fluorine compounds are widely used as chemotherapeutic agents. More recently 18F-labeled compounds have become important in positron emission tomography. Although a variety of fluorinating agents and fluorinating methods are known there are very few known ways of introducing fluorine into electron rich systems such as olefins, aromatics, etc. In fact the great majority of fluorinating agents are nucleophilic. Since fluorine is the most electronegative element known it is not surprising that few electrophilic fluorinating reagents are available. We propose, as part of a FIRCA grant, to prepare and investigate 10-electron isoelectronic Xe(II), Se(IV), Te(IV) and Bi(V) as "power variable electrophilic fluorinating agents". The proposed chemistry is analogous to the chemistry of Iodine (III) that is experiencing a Renaissance. Specifically, ArSeF3, ArTeF3 and Ar3BiF2 along with XeF2 will be investigated as fluorinating agents for olefins. Likewise FXeOSO2F, FXeOSO2CF3 and Xe(OSO2F)2, Xe(OSO2CF3)2 will be investigated as a means of electrophilic introduction of these fluorosulfonate groups into olefins. Biologically active compounds such as fluorosteroids will be prepared along with other medicinally useful fluorocompounds.