FLUORINATED BIOCOMPOUNDS VIA I SALTS & RELATED CHEMISTRY

描述 这项提案的目标是开发新的合成方法来合成 将氟转化为有机化合物。调查人员提议探索两个新的 氟化策略：(I)使用10电子的Ph2SeF3、PhTeF5和Ph3BiF2作为 新型亲电氟化剂及(II)碘物种的反应 与氟化亲核试剂反应。调查人员还提议探索一种新的 一种由烯烃和碘盐环合制备的方法 2，5-二氢呋喃，可作为开发新制剂的先导 治疗艾滋病病毒。研究人员还打算准备其他生物活性物质 化合物，如氟类固醇、蛋白酶和磷酸酶抑制剂，以及 AZT的类似物。

DESCRIPTION The goal of this proposal is to develop new synthetic methods to incorporate fluorine into organic compounds. The investigators propose to explore two new fluorinating strategies: (i) use of 10-electron Ph2SeF3, PhTeF5 and Ph3BiF2 as novel electrophilic fluorinating agents and (ii) reaction of iodonium species with fluorinated nucleophiles. The investigators also propose to explore a new method for cyclization from allenes and iodonium salts to prepare 2,5-dihydrofurans that may serve as leads for the development of new agents to treat HIV. The investigators also intend to prepare other biologically active compounds such as fluorosteroids, protease and phosphatase inhibitors, and analogs of AZT.