FLUORINATED BIOCOMPOUNDS VIA I SALTS & RELATED CHEMISTRY

描述 该提案的目标是开发新的合成方法， 氟转化为有机化合物。调查人员建议探索两个新的 氟化策略：（i）使用10电子Ph 2SeF 3、PhTeF 5和Ph 3BiF 2作为 新的亲电氟化剂和（ii）碘鎓物质的反应 氟化亲核试剂。研究人员还建议探索一种新的 由联烯和碘鎓盐环化制备 2，5-二氢呋喃，可作为开发新药物的先导， 治疗艾滋病研究人员还打算制备其他生物活性物质， 化合物如氟类固醇、蛋白酶和磷酸酶抑制剂，和 AZT类似物。

DESCRIPTION The goal of this proposal is to develop new synthetic methods to incorporate fluorine into organic compounds. The investigators propose to explore two new fluorinating strategies: (i) use of 10-electron Ph2SeF3, PhTeF5 and Ph3BiF2 as novel electrophilic fluorinating agents and (ii) reaction of iodonium species with fluorinated nucleophiles. The investigators also propose to explore a new method for cyclization from allenes and iodonium salts to prepare 2,5-dihydrofurans that may serve as leads for the development of new agents to treat HIV. The investigators also intend to prepare other biologically active compounds such as fluorosteroids, protease and phosphatase inhibitors, and analogs of AZT.