I.Iodonium Chemistry. II. Abiological Self-Assembly

I.碘化学。

• 批准号: 7344653
• 负责人: Peter J Stang
• 金额: $ 9.97万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7344653
• 关键词: Biological; Biosensor; Catalysis; Chemical Agents; Chemistry; Complex; Degenerative Disorder; Detection; Devices; Diagnostic; Disease; Drug Delivery Systems; Enzymes; Goals; Heart; Human; Investigation; Life; Medical; Membrane; Metals; Methodology; Methods; Microtubules; Molecular; Nanotechnology; Nucleic Acids; Object Attachment; Organism; Phospholipids; Play; Preparation; Prion Diseases; Procedures; Process; Production; Purpose; Research; Ribosomes; Role; Running; Science; Shapes; Structure; analytical tool; chemotherapy; combinatorial; design; frontier; improved; innovation; insight; molecular recognition; nanodevice; nanoscale; novel; programs; protein folding; self assembly; self organization; sensor; size

The long term objectives of this research are to develop efficient methods for the preparation of complex, nanoscale molecules with well defined shapes and sizes, by rational design and to provide new insights and gain a better understanding of recognition phenomena and self-assembly processes. Our specific aims are to investigate and understand host-guest interactions of self-assembled 3D molecular cages; prepare, characterize and explore the chemistry of novel, chiral 3D assemblies; explore and develop new ways of characterizing nanoscale supramolecular species; examine self-selection, self-recognition and dynamic phenomenain self-assembly; investigate hierarchical abiological self-assembly and screen for biological activity all new self-assembled supramolecular ensembles. We will use our recently developed abiological coordination driven, directional bonding approach in combination with new methodology and known analytical tools to achieve these goals. As a consequence, chemists will have conceptually new, innovative strategies for the formation of unique, complex, molecules that, in the long term, will facilitate the discovery and production of improved chemical agents and chemotherapy for the treatments of medical disorders. Moreover, also in the long run, this abiological self- assembly procedure will provide the means for the manufacturing of biomedical nanodevices (sensors for diagnostic purposes, new drug delivery systems, etc.) for the better detection and treatment of medical disorders. Likewise,the rationally designed, chiral, self-assembled molecular cages have the potential for selective substrate transformations (enzyme like catalysis) and to act as nanoreactors for unique molecular transformations. Self-assembly is at the heart of countless biological processesthat all living organisms, from the simplest to humans, depend upon. Protein folding, nucleic acid assembly and tertiary structures, ribosomes, phospholipid membranes, microtubules are but representative examples of self-assembly. Insights gained from the proposedabiological self-assembly studies will be applicable to a better and more complete understanding of the complex, not well understood biological self-assembly processes, such as protein folding, that play an important role in such degenerative diseases as Alzheimers, Creutzfeldt-Jakob, and prion diseases.

这项研究的长期目标是开发有效的方法来制备 形状和大小定义良好的复杂纳米级分子，通过合理的设计和提供新的 并对识别现象和自组装过程有更好的理解。我们的 具体目的是研究和理解自组装3D分子的主客体相互作用 笼子；制备、表征和探索新型手性三维组件的化学；探索和开发 表征纳米级超分子物种的新方法；检查自我选择、自我识别和 动态现象自组装；研究层次化非生物自组装和筛选 生物活性所有新的自组装超分子系综。 我们将使用我们最近开发的非生物协调驱动的定向键合方法 结合新的方法和已知的分析工具来实现这些目标。因此， 化学家将在概念上有新的、创新的策略来形成独特、复杂的分子 从长远来看，这将促进发现和生产改进的化学制剂和 用于治疗内科疾病的化疗。而且，从长远来看，这种非生物自我-- 组装程序将提供制造生物医学纳米设备(传感器)的手段 诊断目的、新的药物输送系统等)为了更好地检测和治疗医疗疾病 精神错乱。同样，合理设计的手性自组装分子笼有可能 选择性底物转化(类酶催化)，并作为独特分子的纳米反应器 变形。 自组装是无数生物过程的核心，从最简单的生物到 对人类来说，依赖于。蛋白质折叠，核酸组装和三级结构，核糖体， 磷脂膜、微管只是自组装的典型例子。获得洞察力 由此提出的非生物自组装研究将适用于更好、更完整的 了解复杂的、没有很好理解的生物自组装过程，如蛋白质 折叠，在阿尔茨海默氏症、克雅氏病等退行性疾病中发挥重要作用 普恩病毒病。