I.Iodonium Chemistry. II. Abiological Self-Assembly

本研究的长期目标是开发有效的制备方法 通过合理的设计，具有明确形状和尺寸的复杂的纳米级分子，并提供新的 洞察力和获得更好的理解识别现象和自组装过程。我们 具体的目的是研究和理解自组装三维分子的主客体相互作用 笼;制备，表征和探索新型手性3D组件的化学;探索和开发 表征纳米级超分子物种的新方法;检查自我选择，自我识别和 自组装的动力学现象，研究分级非生物自组装，筛选 所有新的自组装超分子系综。 我们将使用我们最近开发的非生物协调驱动，定向键合方法， 结合新的方法和已知的分析工具来实现这些目标。因此，在这方面， 化学家将有概念上的新的，创新的策略，以形成独特的，复杂的， 从长远来看，这将有助于发现和生产改进的化学制剂， 用于治疗医学疾病的化学疗法。此外，从长远来看，这种非生物的自我- 组装过程将提供用于制造生物医学纳米器件（传感器， 诊断目的、新的药物递送系统等）为了更好地检测和治疗 紊乱同样，合理设计的手性自组装分子笼具有潜在的 选择性底物转化（酶样催化），并作为纳米反应器的独特分子 转变 自我组装是无数生物过程的核心，所有生物体，从最简单的 对人类来说，依赖。蛋白质折叠，核酸组装和三级结构，核糖体， 磷脂膜、微管只是自组装的代表性实例。获得的见解 从生物学上提出的自组装研究将适用于更好、更完整的 理解复杂的，不太了解生物自组装过程，如蛋白质 折叠，在阿尔茨海默氏症，克雅氏病， 朊病毒疾病

The long term objectives of this research are to develop efficient methods for the preparation of complex, nanoscale molecules with well defined shapes and sizes, by rational design and to provide new insights and gain a better understanding of recognition phenomena and self-assembly processes. Our specific aims are to investigate and understand host-guest interactions of self-assembled 3D molecular cages; prepare, characterize and explore the chemistry of novel, chiral 3D assemblies; explore and develop new ways of characterizing nanoscale supramolecular species; examine self-selection, self-recognition and dynamic phenomenain self-assembly; investigate hierarchical abiological self-assembly and screen for biological activity all new self-assembled supramolecular ensembles. We will use our recently developed abiological coordination driven, directional bonding approach in combination with new methodology and known analytical tools to achieve these goals. As a consequence, chemists will have conceptually new, innovative strategies for the formation of unique, complex, molecules that, in the long term, will facilitate the discovery and production of improved chemical agents and chemotherapy for the treatments of medical disorders. Moreover, also in the long run, this abiological self- assembly procedure will provide the means for the manufacturing of biomedical nanodevices (sensors for diagnostic purposes, new drug delivery systems, etc.) for the better detection and treatment of medical disorders. Likewise,the rationally designed, chiral, self-assembled molecular cages have the potential for selective substrate transformations (enzyme like catalysis) and to act as nanoreactors for unique molecular transformations. Self-assembly is at the heart of countless biological processesthat all living organisms, from the simplest to humans, depend upon. Protein folding, nucleic acid assembly and tertiary structures, ribosomes, phospholipid membranes, microtubules are but representative examples of self-assembly. Insights gained from the proposedabiological self-assembly studies will be applicable to a better and more complete understanding of the complex, not well understood biological self-assembly processes, such as protein folding, that play an important role in such degenerative diseases as Alzheimers, Creutzfeldt-Jakob, and prion diseases.