PREVENTIVE ONCOLOGY

实验室最近的研究表明，p53基因发生了突变 随着多种恶性肿瘤的发展。可提供的 癌症易感性的遗传标记提出了许多重要问题 对于这一点，P53充当了一个范例。具体研究目标是： 1.确定中国家庭对载波检测的需求 儿科癌症患者，以P53为范式。 2.制定测试前评估和教育的协议 人口。 3.评估我们为幸存者提供的癌症预防教育课程 儿童癌症，并研究风险评估的重要性在 癌症预防教育的效果。 4.筛查170名有肉瘤病史的人是否符合宪法 P53突变，并确定突变在 儿童肉瘤的亚型；研究这些亚型的家族史 并研究其疾病的自然病史。 作为预防肿瘤学学术奖的获得者，我还将 接受癌症预防方面的培训，包括在 流行病学、生物统计学和癌症控制。

Recent studies in the laboratory have linked mutations in the p53 gene with development of many types of malignancies. The availability of a genetic marker for cancer predisposition raises many important questions for which p53 acts as a paradigm. The specific research aims are: 1. To determine the demand for carrier testing among families of pediatric cancer patients, using p53 as a paradigm. 2. To develop a protocol for pre-test evaluation and education in this population. 3. To assess our curriculum for cancer prevention education in survivors of childhood cancer, and study the importance of risk assessment in efficacy of cancer prevention education. 4. To screen 170 individuals with a history of sarcoma for constitutional p53 mutations and determine the prevalence of mutations among the subtypes of childhood sarcoma; to study family histories of these patients and to study the natural history of their diseases. As a recipient of a Preventive Oncology Academic Award, I will also pursue training in cancer prevention, including formal coursework in epidemiology, biostatistics and cancer control.