PREVENTIVE ONCOLOGY
PREVENTIVE ONCOLOGY
批准号:
2084214
负责人:
Lisa R. Diller
金额:
$8.82万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1993
资助国家:
美国
项目状态:
已结题
起止时间:
1993-02-01 至 1998-01-31
关键词:
cancer prevention cancer risk curriculum education evaluation /planning family genetics gene mutation genetic counseling genetic markers human data mass screening neoplasm /cancer education neoplasm /cancer epidemiology neoplasm /cancer genetics pediatric neoplasm /cancer postgraduate education questionnaires sarcoma tumor suppressor genes
中文摘要
最近的实验室研究已经将p53基因的突变与
伴随着多种恶性肿瘤的发展。 的可用性
癌症易感性的遗传标记提出了许多重要的问题
其中p53是一个范例。 具体的研究目标是:
1.为了确定携带者检测的家庭需求,
儿科癌症患者,使用p53作为范例。
2.为了制定一个测试前评估和教育的协议,
人口
3.评估我们的幸存者癌症预防教育课程
儿童癌症的风险评估,并研究风险评估的重要性,
癌症预防教育的效果。
4.筛选170例有肉瘤病史的个体,
p53突变,并确定突变的患病率,
儿童肉瘤亚型;研究这些家族史
患者和研究他们的疾病的自然史。
作为预防肿瘤学学术奖的获得者,我还将
接受预防癌症的培训,包括以下方面的正式课程:
流行病学、生物统计学和癌症控制。
英文摘要
Recent studies in the laboratory have linked mutations in the p53 gene
with development of many types of malignancies. The availability of a
genetic marker for cancer predisposition raises many important questions
for which p53 acts as a paradigm. The specific research aims are:
1. To determine the demand for carrier testing among families of
pediatric cancer patients, using p53 as a paradigm.
2. To develop a protocol for pre-test evaluation and education in this
population.
3. To assess our curriculum for cancer prevention education in survivors
of childhood cancer, and study the importance of risk assessment in
efficacy of cancer prevention education.
4. To screen 170 individuals with a history of sarcoma for constitutional
p53 mutations and determine the prevalence of mutations among the
subtypes of childhood sarcoma; to study family histories of these
patients and to study the natural history of their diseases.
As a recipient of a Preventive Oncology Academic Award, I will also
pursue training in cancer prevention, including formal coursework in
epidemiology, biostatistics and cancer control.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
SIOP Boston 2010 Annual Congress
-
批准号:8005470
-
项目类别:
-
资助金额:$0.8万
-
财政年份:2010
-
负责人:Lisa R. Diller
-
依托单位:
PREVENTIVE ONCOLOGY
-
批准号:2330626
-
项目类别:
-
资助金额:$8.8万
-
财政年份:1993
-
负责人:Lisa R. Diller
-
依托单位:
PREVENTIVE ONCOLOGY
-
批准号:2084215
-
项目类别:
-
资助金额:$8.82万
-
财政年份:1993
-
负责人:Lisa R. Diller
-
依托单位:
PREVENTIVE ONCOLOGY
-
批准号:2084216
-
项目类别:
-
资助金额:$8.82万
-
财政年份:1993
-
负责人:Lisa R. Diller
-
依托单位:
PREVENTIVE ONCOLOGY ACADEMIC AWARD
-
批准号:3076841
-
项目类别:
-
资助金额:$7.3万
-
财政年份:1993
-
负责人:Lisa R. Diller
-
依托单位:
海外基金