PREVENTIVE ONCOLOGY

最近的实验室研究已经将p53基因的突变与 伴随着多种恶性肿瘤的发展。 的可用性 癌症易感性的遗传标记提出了许多重要的问题 其中p53是一个范例。 具体的研究目标是： 1.为了确定携带者检测的家庭需求， 儿科癌症患者，使用p53作为范例。 2.为了制定一个测试前评估和教育的协议， 人口 3.评估我们的幸存者癌症预防教育课程 儿童癌症的风险评估，并研究风险评估的重要性， 癌症预防教育的效果。 4.筛选170例有肉瘤病史的个体， p53突变，并确定突变的患病率， 儿童肉瘤亚型;研究这些家族史 患者和研究他们的疾病的自然史。 作为预防肿瘤学学术奖的获得者，我还将 接受预防癌症的培训，包括以下方面的正式课程： 流行病学、生物统计学和癌症控制。

Recent studies in the laboratory have linked mutations in the p53 gene with development of many types of malignancies. The availability of a genetic marker for cancer predisposition raises many important questions for which p53 acts as a paradigm. The specific research aims are: 1. To determine the demand for carrier testing among families of pediatric cancer patients, using p53 as a paradigm. 2. To develop a protocol for pre-test evaluation and education in this population. 3. To assess our curriculum for cancer prevention education in survivors of childhood cancer, and study the importance of risk assessment in efficacy of cancer prevention education. 4. To screen 170 individuals with a history of sarcoma for constitutional p53 mutations and determine the prevalence of mutations among the subtypes of childhood sarcoma; to study family histories of these patients and to study the natural history of their diseases. As a recipient of a Preventive Oncology Academic Award, I will also pursue training in cancer prevention, including formal coursework in epidemiology, biostatistics and cancer control.