PREVENTIVE ONCOLOGY ACADEMIC AWARD

预防肿瘤学学术奖

• 批准号: 2084125
• 负责人: KATHERINE A MCGLYNN
• 金额: $ 9.18万
• 依托单位: FOX CHASE CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-07-01 至 1996-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2084125
• 关键词: DNA replication; adenocarcinoma; blood donor; cancer prevention; cancer risk; colon neoplasms; environment related neoplasm /cancer; enzyme linked immunosorbent assay; ferritin; human morbidity; human subject; iron storage disorder; neoplasm /cancer education; neoplasm /cancer epidemiology; nucleic acid probes; preneoplastic state; questionnaires; restriction fragment length polymorphism; serum

One of the biggest challenges facing Preventive Oncology today is the better definition of high risk individuals. An ever growing body of data is transmitted to the public concerning cancer causation. This bombardment of information, while broadening our understanding, serves us poorly if conveys the impression that everything is carcinogenic and that the risk is universal. Preventive Oncology must begin to send the message that it is the rare exposure that is absolutely carcinogenic. We cannot consider the exposure without equal consideration of the genetic background which it affects. The challenge, then, is to find ways of identifying the susceptible subset of the population. I believe that susceptibility will increasingly be identified by biochemical means and the scientists who will move to the forefront in this identification are biochemical epidemiologists. In this emerging field, it is necessary to equip researchers with both the discipline of epidemiology and the skill of laboratory science. This award would provide me with the perfect opportunity to move into that arena. The training program which I have proposed will increase my skills in all areas of molecular oncology. I have chosen the laboratories and courses to complement each other and fill in those areas most necessary to a well founded biochemical epidemiologist. I will continue to teach during the course of the award, and hope stimulate the thinking of future researchers in this field. I have outlined a research program, based on the relationship between body iron stores and cancer susceptibility, which promises to serve as the starting point for a larger, more diverse program of biological susceptibility. This award will allow me to complete the necessary training, continue teaching, and launch a program which, I feel, will likely prove to be of great value to Preventive Oncology.

当今预防肿瘤学面临的最大挑战之一是 更好地定义高危人群。 不断增长的数据体 传播给公众有关癌症的原因。 这次轰炸 信息，虽然扩大了我们的理解，为我们服务不好， 给人的印象是一切都是致癌的， 是普遍的。 预防肿瘤学必须开始发出这样的信息， 是绝对致癌的罕见接触。 我们不能认为 没有平等考虑遗传背景的暴露， 它影响。 因此，挑战在于找到识别 人群中的易感亚群。 我相信，易感性将越来越多地被确定为 生物化学手段和科学家谁将移动到最前沿， 鉴定是生化流行病学家。 在这一新兴领域， 有必要使研究人员具备以下两个学科： 流行病学和实验室科学技能。 该奖项将提供 给我一个进入那个竞技场的绝佳机会 我所建议的培训计划将提高我在以下方面的技能 分子肿瘤学的所有领域。 我选择了实验室， 课程相辅相成，填补那些最必要的领域， 一位有充分根据的生化流行病学家 我会继续教， 获奖的过程，并希望激发对未来的思考 该领域的研究人员。 我已经概述了一个研究计划，基于 体内铁储存与癌症易感性之间的关系， 承诺作为一个更大，更多样化的计划的起点 生物易感性的证据 这个奖项将使我能够完成 必要的培训，继续教学，并启动一个项目，我觉得， 很可能对预防肿瘤学有很大的价值。