EPIDEMIOLOGY OF BODY IRON STORES & COLONIC POLYPS

身体铁储存的流行病学

• 批准号: 3460155
• 负责人: KATHERINE A MCGLYNN
• 金额: $ 10.75万
• 依托单位: FOX CHASE CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-01 至 1997-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3460155
• 关键词: adenocarcinoma; blood chemistry; cancer risk; colon neoplasms; colorectal neoplasms; dietary iron; environment related neoplasm /cancer; enzyme linked immunosorbent assay; gastrointestinal imaging /visualization; gel electrophoresis; genetic polymorphism; human subject; iron storage disorder; neoplasm /cancer diagnosis; neoplasm /cancer epidemiology; neoplasm /cancer genetics; nutrition related neoplasm /cancer; nutrition related tag; polymerase chain reaction; preneoplastic state; questionnaires; restriction fragment length polymorphism; southern blotting; transferrin receptor

Epidemiologic studies have identified an association between iron and colorectal cancer. To date, no studies have examined the association between iron and a precursor lesion of colorectal cancer, adenomatous colonic polyps. In that the large majority of cancers arise from adenomatous polyps, it would be of great importance to determine if an iron-polyps relationship exists. The primary objective of this project is to test the hypothesis that there is an association between elevated body iron stores and adenomatous polyps of the colon. We will examine this hypothesis in a case-control study of six hundred men with and without polyps and in a substudy among a screening population of 120 cases and controls with and without polyps. Body iron stores, as determined by serum ferritin and transferrin levels, will be correlated with presence or absence of disease. The secondary objective of this project is to examine, within the framework of the case-control study, the genetic and environmental influences on body iron stores. To examine the genetic factors, we will use DNA polymorphisms to correlate genetic variants at iron related loci with serum measures of iron stores. To examine environmental factors, we will collect dietary information from all participants in the study and correlate the dietary data with that of the serum and genetic measures. The identification of iron as a risk factor for adenomatous polyps would be of great significance given the high incidence of polyps in older age groups and the ability to easily decrease iron stores, and thereby, possibly decrease the risk of colorectal carcinoma.

流行病学研究已经确定了铁与 结肠直肠癌 到目前为止，还没有研究调查这种联系。 铁与结直肠癌的前期病变，腺瘤性 结肠息肉 因为绝大多数癌症都是由 腺瘤性息肉，这将是非常重要的，以确定是否 存在铁息肉关系。 该项目的主要目标是测试假设， 是体内铁储备升高和腺瘤性息肉之间的联系 的结肠。 我们将在一项病例对照研究中检验这一假设， 600名患有和没有息肉的男性，在一项筛查的子研究中， 120例患者和对照人群，有和无息肉。 机体铁 通过血清铁蛋白和转铁蛋白水平测定， 与疾病的存在或不存在相关。 该项目的第二个目标是在框架内审查 在病例对照研究中，遗传和环境对身体的影响 铁商店 为了检测遗传因素，我们将使用DNA多态性 将铁相关基因座的遗传变异与血清中 铁商店 为了研究环境因素，我们会收集食物样本， 研究中所有参与者的信息，并将饮食 与血清和遗传测量的数据。 铁作为腺瘤性息肉的危险因素的鉴定将是 考虑到老年人息肉的高发病率， 能轻易地减少铁的储存，因此， 可能会降低患结肠直肠癌的风险。