PSYCHOENDOCRINOLOGY OF ANABOLIC STEROID CYCLING

合成代谢类固醇循环的心理内分泌学

• 批准号: 2120810
• 负责人: PAUL J PERRY
• 金额: $ 26.97万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-01-21 至 1996-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2120810
• 关键词: aggression; blood chemistry; clinical depression; drug adverse effect; drug detection; endocrine pharmacology; hormone regulation /control mechanism; human subject; hypogonadism; hypothalamic pituitary axis; liver function; male; psychobiology; psychological tests; sex behavior; testis; testosterone; urinalysis

AIMS: This goal of this study is to define and contrast the pharmacodynamic effects of physiologic and supraphysiologic testosterone (T) doses on the hypothalamic-pituitary-testicular axis, hepatic function, and psychosexual function. METHODS: This study will use a double-blind design to test 6 hypotheses that include: 1) prolonged administration of supraphysiologic doses of T in men causes a suppression of the pituitary gonadal axis which gives rise to a state of transient hypogonadism after drug withdrawal, 2) the hypogonadism which accompanies T withdrawal results from a defect in hypothalamic rather than pituitary or testicular function, 3) administration of supraphysiologic doses of T in men increases the level of aggression that correlates with the increased serum T concentrations, 4) the temporary hypogonadism which accompanies T withdrawal results in dysphoria that correlates with the decreased serum concentrations of T, 5) testosterone cypionate (TC) at both physiologic and supraphysiologic doses is eliminated as a first order kinetic elimination process, and 6) prolonged administration of supraphysiologic doses of T in men produces prolonged changes in subjects' T laboratory endocrine parameters that have greater sensitivity and specificity for identification of abuse than traditional urine screens. Thirty normal- subject volunteers naive to anabolic steroids, following a 2 week placebo lead-in, will be randomly assigned to receive TC weekly doses of 100, 250, or 500 mg for 14 consecutive weeks. Subjects will then receive 12 consecutive weekly placebo injections to examine the withdrawal effects TC. Biweekly laboratory studies will include a general chemistry screen, serum and urinary steroid assays, lipid screening, liver function tests, and thyroid function tests. Psychiatric symptomatology will be prospectively monitored biweekly using self-report measures and single- blind observatiorial measures. Measures will include the Buss-Durkee Hostility Inventory, the Scale for Suicidal Ideation, Hamilton Depression and Anxiety Scales, Modified Manic State Rating Scale, and the Brief Psychiatric Rating Scale and the Symptom Checklist 90. Urine drugs screens will be repeated every fourth week. All subjects will be monitored closely during the study for medical and psychiatric complications of T use. Subjects demonstrating significant medical or psychiatric dysfunction will be discontinued from the study and referred for further medical or psychiatric evaluation. IMPLICATIONS: This study will l) characterize the long-term sequelae and short-term neuropsychiatric and biomedical effects of the use of physiologic and supraphysiologic T doses and 2) improve techniques for analytical testing of AAS covert usage.

目的：本研究的目的是定义和对比 生理和超生理睾酮的药效学作用 (T)对下丘脑-垂体-睾丸轴的剂量，肝功能， 和性心理功能方法：本研究将采用双盲 设计测试6个假设，包括：1）长期给药 男性超生理剂量的T会抑制垂体 性腺轴，引起暂时性性腺功能减退的状态后， 药物戒断，2）伴随T戒断的性腺功能减退 是由于下丘脑而不是垂体或睾丸的缺陷造成的 功能，3）在男性中给予超生理剂量的T 增加了与血清浓度增加相关的攻击性水平 T浓度，4）暂时性性腺功能减退，伴随T 戒断导致烦躁不安，这与血清 5）环戊丙酸睾酮（TC）， 并且超生理剂量作为一级动力学被消除 消除过程，和6）延长超生理给药 男性的T剂量在受试者的T实验室中产生长期的变化 内分泌参数，具有更大的敏感性和特异性， 比传统的尿液筛查更容易识别滥用。30个正常- 受试者志愿者未接受过合成代谢类固醇，在接受2周安慰剂治疗后 导入期，将被随机分配接受TC每周剂量100，250， 或500 mg连续14周。受试者将接受12次 连续每周一次安慰剂注射，以检查戒断效应 TC.每两周一次的实验室检查将包括一般化学筛查， 血清和尿类固醇测定，脂质筛查，肝功能检查， 和甲状腺功能测试 精神病学将是 前瞻性监测每两周使用自我报告的措施和单- 盲目的观察。措施将包括巴士-德基 敌意问卷、自杀意念量表、汉密尔顿抑郁症 和焦虑量表，改良躁狂状态评定量表，和简要 90.第90章我的世界尿液药物筛查 将每四周重复一次。将密切监测所有受试者 在研究过程中使用T的医学和精神并发症。 表现出显著医学或精神功能障碍的受试者将 中止研究并转诊接受进一步医疗或 精神评估含义：这项研究将l）表征 长期后遗症和短期神经精神和生物医学影响 使用生理和超生理T剂量，2）改善 AAS秘密使用的分析测试技术。