COGNITIVE FUNCTIONING OF ABSTINENT COCAINE ABUSERS

1.计划对神经心理测验进行纵向研究 一群吸食可卡因的人的表现，他们已经戒除了 八天，通过比较他们的 与匹配的非药物对照组的表现相同。这两个 团体(现在)[26岁至33岁]，将成为非治疗社区 全国重点研究的黑人受试者 协作性围产期项目(NCPP)，从出生到7岁。 因此，全面的前物质使用数据将可用于 控制长期使用可卡因的影响。还有，系统化 关于这些科目的学校记录数据，从他们13岁到15岁 年龄(加州成就考试成绩、成绩和出勤记录 在9年级期间)将在费城学校提供 作为额外的前体物质使用控制。 2.将对两组住院的可卡因滥用者进行两次评估 在相同的神经心理测试程序上的不同时间段 以上社区非治疗组，并将比较他们的 与相匹配的控制组的表现。这些住院病人中的一组 将被评估为禁欲8天和22天，另一名将被评估 分别在禁欲8天和35天进行评估。这些住院的可卡因 这些团体都将至少使用可卡因三年，而且他们将 被DSM-III-R和SCID诊断为可卡因滥用者。可卡因将会是 他们的主要毒品问题，而且他们只会使用酒精， 有限度地吸食大麻或其他非法物质( 上文提到的社区团体)。 将确定是否发现任何功能缺陷 对于可卡因滥用者来说，与戒除可卡因的持续时间有关。

1. A longitudinal study is planned of the neuropsychological test performance of a group of cocaine abusers, who have been abstinent for eight days, to determine impairment in functioning, by comparing their performance with that of a matched non-drug control group. These two groups (now) [26 to 33] years of age), will be non-treatment community black subjects who had been studied intensively in the National Collaborative Perinatal Project (NCPP), from birth to seven years of age. Thus, the comprehensive pre-substance use data will be available to control for the effects of long-term cocaine use. Also, systematic school record data on these subjects, from when they were 13 to 15 years of age (California Achievement Test Scores, grades and attendance records during the 9th grade) will be available from the Philadelphia School District, to utilize as additional pre-substance use controls. 2. Two groups of hospitalized cocaine abusers will be assessed at two different time periods on the same neuropsychological test procedures as the community non-treatment groups above, and will be compared on their performance with matched control groups. One of these inpatient groups will be assessed at 8 days and 22 days of abstinence, and the other will be assessed at 8 days and 35 days of abstinence. These inpatient cocaine groups will all have used cocaine for at least three years, and they will be diagnosed as cocaine abusers by DSM-III-R and SCID. Cocaine will be their primary drug problem, and they will only have used alcohol, marijuana or other illicit substances to a limited extent (as will the community groups referred to above). It will be determined whether any deficit in functioning that is found for cocaine abusers is related to the duration of abstinence for cocaine.