Investigating a novel factor impacting stem cell development

研究影响干细胞发育的新因素

• 批准号: DP200103293
• 负责人: Prof Roger Pocock
• 金额: $ 26.53万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200103293
• 关键词: Investigating; novel; factor; impacting; stem

This project aims to investigate how stem cells are controlled during animal development, by exploring how a specific protein, essential for embryonic development, controls cell fate decisions during the early stages of life. This project expects to generate new knowledge in stem cell biology, embryonic development, and general mechanisms controlling cell fates, using innovative approaches in gene editing and high-throughput imaging. Expected outcomes of this project include enhanced capacity for fundamental stem cell biology in Australia. This should provide significant benefits, such as training of young Australian researchers in frontier technologies, and new knowledge in fundamental aspects of life, including embryonic development.

该项目旨在通过探索胚胎发育所必需的特定蛋白质如何在生命的早期阶段控制细胞命运决定，来研究干细胞在动物发育过程中的控制方式。该项目预计将产生干细胞生物学，胚胎发育和控制细胞命运的一般机制的新知识，使用基因编辑和高通量成像的创新方法。该项目的预期成果包括提高澳大利亚基本干细胞生物学的能力。这将带来巨大的好处，例如对澳大利亚年轻研究人员进行前沿技术培训，并获得包括胚胎发育在内的生命基本方面的新知识。