CILIARY MECHANICS IN THE ADULT ORGAN OF CORTI

成人柯蒂氏器官的纤毛力学

• 批准号: 3424735
• 负责人: RICHARD John HALLWORTH
• 金额: $ 2.54万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-04-01 至 1995-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3424735
• 关键词: biomechanics; cilium; cochlea; ear hair cell; laboratory mouse; organ of Corti; psychoacoustics; voltage /patch clamp

The long-term objective of this study is to examine force generation by hair cell cilia in the adult organ of Corti. Knowledge of cilia physiology is central to our understanding of cochlear transduction. Further, force generation by cilia is a likely source of mechanical energy input to the cochlea, and may therefore contribute to cochlear frequency selectivity and the generation of acoustic emissions. Specifically, the studies are designed to help develop a preparation to enable in vitro studies of cochlear hair cell cilia.

本研究的长期目标是通过以下方式检查部队生成： 成年Corti器官中的毛细胞纤毛。 纤毛知识 生理学是我们理解耳蜗传导的核心。 此外，纤毛产生的力可能是机械力的来源。 能量输入到耳蜗，因此可以有助于耳蜗 频率选择性和声发射的产生。 具体来说，这些研究旨在帮助开发一种制剂， 能够在体外研究耳蜗毛细胞纤毛。