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CHORDA-LINGUAL NERVE INJURY AND CHEMOSENSORY PERFORMANCE

脊索-舌神经损伤和化学感觉性能

基本信息

批准号：
2131090
负责人：
JOHN R ZUNIGA
金额：
$ 3.02万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
1992
资助国家：
美国
起止时间：
1992-09-30 至 1995-09-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2131090
关键词：
atrophy chemoreceptors citrates denervation human subject injury innervation microscopy oral pharyngeal surgery postoperative complications sensory discrimination sensory receptors taste taste buds taste threshold tongue videotape /videodisc visceral afferent nerve

项目摘要

Description: (Adapted From The Applicant's Abstract) The objective of this project is to evaluate the impact of severe chorda-lingual nerve injury on gustation and taste bud density, specifically the capacity of human subjects with unilateral nerve injury to detect and scale the strength of different concentrations of citrate applied to spatially- matched, isolated, discrete regions of the anterior tongue tip. The anatomical characteristics of fungiform taste buds within the same site tested for citrate taste perception will be investigated using a non- destructive staining method and videomicroscopy. It is hypothesized that severe injury to the chorda-lingual nerve in humans results in the loss or depletion of taste sensibility due in part to denervation atrophy of fungiform taste buds. Information from these studies will provide a method to diagnose hypogeusias following injury to the chorda- lingual innervation in humans and should thus contribute to the understanding and treatment of taste disorders which involve the chorda- lingual nerve. Citrate detection thresholds and subjective strengths of taste intensity will be assessed in healthy men and women with unilateral severe chorda- lingual nerve injury as a result of dental or maxillofacial surgery. A two-alternative forced choice, modified staircase procedure will be used to derive threshold. Cross-modal magnitude matching functions for taste intensity judgement will be obtained for five concentrations of citrate, and measures of perceived strength will de determined. The right and left tongue tip surface will be tested to assess the effect of selective nerve damage on citrate taste perception. Citrate solutions will be delivered to an enclosed, self-retained chamber reinforced to the surface of the right/left tongue tip so that only a discrete and isolated surface area of the tongue will be tested. The taste buds bathed by stimuli within the chamber will be distinguished by methylene blue stain and recorded by videomicroscopy. The number of fungiform papillae and pores per unit area will be determined so that the relationship of discriminative taste performance for a known number of taste buds can be examined. Comparisons of global (i.e., whole mouth) threshold and suprathreshold scales of citrate taste intensity will be made to elucidate the effect of unilateral nerve injury on global taste perception.

描述：(改编自申请人的摘要)目标本项目旨在评估严重的弦-舌神经的影响。对味觉和味蕾密度的损害，特别是对人类单侧神经损伤受试者检测和测量不同浓度的柠檬酸盐在空间上的应用强度匹配的、孤立的、不连续的舌尖前部区域。这个同一部位菌状味蕾的解剖学特征柠檬酸盐味觉测试将使用非破坏性染色方法和视频显微镜检查。这是假设的人类舌索神经的严重损伤会导致部分由于丧失神经而导致的味觉丧失或丧失菌状味蕾萎缩。来自这些研究的信息将提供了一种诊断脊索损伤后低血糖的方法- 人类的语言神经支配，因此应该有助于对涉及脊索的味觉障碍的认识和治疗舌神经。柠檬酸的检测阈值和味觉强度的主观强度将在患有单侧严重脊索的健康男性和女性身上进行评估- 牙科或颌面外科手术引起的舌神经损伤。一个两种选择强制选择，将使用修改后的楼梯程序以推导出阈值。味觉的跨模幅值匹配函数将对五种浓度的柠檬酸盐进行强度判断，而感知力量的衡量标准将被确定。右翼和将左侧舌尖表面进行测试，以评估选择性治疗的效果柠檬酸味觉的神经损伤。柠檬酸盐溶液将是送到一个封闭的、自留式的腔体中，右/左舌尖的表面，因此只有一个离散的和将测试舌头的隔离表面积。味蕾沐浴在室内的刺激物会被亚甲基区别开来蓝色染色，并用视频显微镜记录。菌类的数量将确定单位面积的乳头和毛孔，以便已知数的辨别性口味表现之间的关系可以检查味蕾。全局(即整个嘴巴)的比较柠檬酸味道强度的阈值和阈值以上等级将是旨在阐明单侧神经损伤对整体味觉的影响感知力。