IRON DEFICIENCY ANEMIA AND INFANT BEHAVIOR

拟议的FIRCA赠款延长并延长了为期五年的美国-智利 缺铁性贫血行为效应的协作性研究 在婴儿期。FIRCA奖涉及正在进行的项目的研究II。 第二项研究将确定是否有一个不同的时期 缺铁性贫血对行为影响的易感性 描述情感、注意力、活动和 6岁时确诊为贫血的婴儿的神经生理成熟， 12岁，或18岁(每岁100人)。另一组为 每个年龄段的非贫血婴儿将提供基线数据 保持较好铁状态的儿童的发育进展。 研究II还侧重于如何改善儿童的行为和发展 患缺铁性贫血的婴儿。之前的研究已经 研究表明，行为改变和较低的发育测试分数不会 在大多数贫血婴儿中使用铁剂治疗后情况有所改善 入学方面的差异仍然很明显。这项研究将 确定除铁以外是否还提供以家庭为基础的干预 治疗可以纠正改变的行为，如果干预更多 在生命的第一年或第二年有效。贫血和 每个年龄段的非贫血婴儿将被随机分配到铁摄入量 单独治疗或铁剂治疗加家庭支持计划 孩子的发展。将行为和发展进行比较 干预前和干预后6个月和12个月。FIRCA奖 将实现三个新目标：1)培训智利联合调查员 行为分析，2)允许智利的神经生理学实验室 使用改进的设备和技术研究神经生理学 在缺铁性贫血中成熟，以及3)允许智利 共同调查人员修改早期干预计划，使其 反映了该领域的最新、最新的思想，但在文化上 对智利很敏感。因此，FIRCA的赠款将促进 智利的合作者，以便他们可以在新的 并将允许智利的合作机构INTA 扩展其作为营养相关资源的长期功能 在整个拉丁美洲进行调查。

The proposed FIRCA grant extends and expands a five-year U.S.-Chile collaborative study of the behavioral effects of iron deficiency anemia in infancy. The FIRCA award relates to Study II of the ongoing project. Study II will determine if there is a period of differential vulnerability to behavioral effects of iron deficiency anemia by characterizing alterations in affect, attention, activity, and neurophysiologic maturation of anemic infants who are identified at 6, 12, or 18 mos of age (n = 100 at each age). A comparison group of nonanemic infants at each age will provide baseline data for developmental progressions in children who maintain better iron status. Study II also focuses on ways to improve the behavior and development of infants who do develop iron deficiency anemia. Previous studies have shown that altered behavior and lower developmental test scores do not improve with iron therapy in most anemic infants and that behavioral differences are still apparent at school entry. This study will determine if providing family-based intervention in addition to iron therapy can correct the altered behavior and if intervention is more effective in the first or in the second year of life. Anemic and nonanemic infants at each age will be randomly assigned to receive iron therapy alone or iron therapy plus a home-based program of support for the child's development. Behavior and development will be compared before and after six and twelve months of intervention. A FIRCA award will accomplish three new goals: 1) to train Chilean co-investigators in behavioral analyses, 2) to allow the neurophysiologic laboratory in Chile to use improved equipment and techniques for studying neurophysiologic maturation in iron deficiency anemia, and 3) to permit Chilean co-investigators to modify the early intervention program so that it reflects the most current, thinking in the field and yet is culturally sensitive to Chile. The FIRCA grant would thus foster the development of Chilean collaborators so that they may achieve leadership roles in new areas and would allow INTA, the collaborating institution in Chile, to expand its longstanding function as a resource for nutrition related investigations throughout Latin America.