Brain and Behavior in Early Iron Deficiency Administrative Core

早期缺铁的大脑和行为管理核心

• 批准号: 7904279
• 负责人: BETSY LOZOFF
• 金额: $ 12.91万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7904279
• 关键词: Accounting; Address; Adopted; Affect; Anemia; Animal Model; Basic Science; Behavior; Behavioral; Biochemical; Brain; Brain Hypoxia-Ischemia; CNS processing; California; Child; Classification; Clinical; Clinical Investigator; Cocaine; Cognition; Collaborations; Conflict (Psychology); Corpus striatum structure; Country; Developed Countries; Developing Countries; Development; Diffuse; Disadvantaged; Disease; Effectiveness; Electrophysiology (science); Employee Strikes; Event-Related Potentials; Experimental Models; Fetal Alcohol Exposure; Financial compensation; Funding; Genes; Genomics; Head; Hippocampus (Brain); Human; Impulsivity; Infant; Interdisciplinary Study; Intervention; Investigation; Iron; Knowledge; Laboratories; Lead; Learning; Link; Long-Term Effects; Measures; Mercury; Michigan; Minnesota; Minority; Modeling; Monkeys; Mothers; Nutrient; Oligodendroglia; Outcome; Pennsylvania; Perinatal; Pharmaceutical Preparations; Population; Positron-Emission Tomography; Pregnancy; Pregnant Women; Primates; Process; Program Research Project Grants; Progress Reports; Research; Research Design; Research Personnel; Risk; Rodent; Rodent Model; Role; Scientist; Staging; Structure; System; Techniques; Texas; Time; Universities; Wisconsin; Woman; Work; austin; behavior measurement; brain behavior; brain tissue; deprivation; design; high risk; improved; infancy; infant of diabetic mother; innovation; interdisciplinary collaboration; meetings; monoamine; myelination; neurotoxic; neurotoxicity; neurotransmission; novel; postnatal; premature; prenatal; prevent; programs; relating to nervous system; response; teenage mother; trend; young mother

The overall purposes of this program-project grant (PPG) are to understand how iron deficiency alters brain and behavior in early development and identify interventions that will correct or prevent ill effects in the shortand long-term. Up to 75% of women worldwide are anemic during pregnancy, with about half due to iron deficiency. In developing countries, 46-66% of children < 4 years are anemic, again with half attributed to iron deficiency, and iron deficiency disproportionately affects poor and/or minority mothers and infants everywhere. Yet there are still important unanswered questions about the brain and behavior effects of early iron deficiency. In the next 5 years, the PPG will focus on 1) timing of iron deficiency in relation to different stages of brain development, 2) timing of iron repletion to ameliorate short-term effects and prevent longterm consequences for brain and behavior, and 3) in-depth study of short- and long-term effects and the processes that account for them. PPG involves 4 projects (1 human infant, 2 monkey, 1 rodent) supported by 3 cores (administrative, analytical, and statistical).The component projects and cores, with interdisciplinary collaboration among leading clinical and basic science researchers, are tightly linked conceptually and methodologically, designed so that each has a special but complementary role. Project I (human infant) will be a systematic investigation of brain and behavior effects of pre- v. postnatal v. combined pre- and postnatal iron deficiency in human infants and the timing of iron treatment. Project II (Davis monkey) will use an experimental model to pursue its novel finding that prenatal iron deprivation produced a behavioral profile of reduced inhibition and increased impulsivity, despite iron repletion. Project III (Madison monkey) will assess brain-behavior effects of combined pre- and postnatal iron deficiency in infants born to young mothers - a naturalistic model directly relevant to vulnerable human populations (developing countries, adolescent mothers). Project IV (developing rodent) will focus on the effectiveness of iron therapy at different times in brain development in preventing genomic, biochemical, structural, and behavioral alterations in adulthood. It will also consider the potential for neurotoxicity with too much iron following early iron deficiency. With close integration, all projects assess neural and behavioral development. Each uses innovative approaches to assess the brain (e.g., electrophysiology in Project I, PET with drug challenge in Project II, brain tissue in Project III, and regional genomics in Project IV). Individually, each project represents a substantial leap beyond previous research on early iron deficiency. Collectively, the program will make major contributions to understanding, treating, and preventing brain and behavior effects of iron deficiency, the world's most common single nutrient disorder.

该计划项目拨款 (PPG) 的总体目的是了解缺铁如何改变大脑 和早期发育中的行为，并确定纠正或预防短期不良影响的干预措施 长期。全球高达 75% 的女性在怀孕期间患有贫血，其中约一半是由铁引起的 不足。在发展中国家，46-66% 的 4 岁以下儿童患有贫血，其中一半归因于贫血 缺铁，缺铁对贫困和/或少数民族母亲和婴儿的影响尤为严重 到处。然而，关于早期儿童对大脑和行为的影响，仍有一些重要的未解之谜。 缺铁。在未来 5 年中，PPG 将重点关注 1) 与不同疾病相关的缺铁时机。 大脑发育阶段，2) 补充铁的时机以改善短期影响并预防长期影响 对大脑和行为的影响，以及3）深入研究短期和长期影响以及 解释它们的过程。 PPG 涉及 4 个项目（1 个人类婴儿、2 个猴子、1 个啮齿动物），由 3个核心（管理、分析和统计）。组成项目和核心，具有跨学科性 领先的临床和基础科学研究人员之间的合作，在概念和概念上紧密相连 在方法论上，设计使每个人都有特殊但互补的作用。项目 I（人类婴儿）将 对产前、产后、结合产前和产后的大脑和行为影响进行系统的研究 人类婴儿产后缺铁和铁治疗的时机。项目二（戴维斯猴）将使用 一个实验模型来追求其新发现，即产前缺铁会产生行为特征 尽管补充了铁，但抑制作用却减少了，冲动性增加了。项目 III（麦迪逊猴）将 评估婴儿产前和产后缺铁对大脑行为的影响 母亲——与弱势群体（发展中国家、 青春期的母亲）。项目 IV（开发啮齿动物）将重点研究铁疗法在不同时期的有效性。 大脑发育中预防基因组、生化、结构和行为改变的时间 成年期。它还将考虑早期铁剂摄入过多后可能产生的神经毒性。 不足。通过紧密结合，所有项目都评估神经和行为发展。每个项目都使用创新方法来评估大脑（例如，项目 I 中的电生理学、项目 II 中的药物挑战 PET、项目 III 中的脑组织以及项目 IV 中的区域基因组学）。就单个项目而言，每个项目都代表着对早期铁缺乏症的先前研究的重大飞跃。总的来说，该项目将为理解、治疗和预防缺铁（世界上最常见的单一营养失调）对大脑和行为的影响做出重大贡献。