IMPROVED POLYMERIC RESTORATIVE THROUGH MOLECULAR DESIGN

通过分子设计改进聚合物修复体

• 批准号: 2130712
• 负责人: J DAVID EICK
• 金额: $ 88.75万
• 依托单位: UNIVERSITY OF MISSOURI KANSAS CITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-03-15 至 1996-03-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2130712
• 关键词: biomaterial compatibility; biomaterial development /preparation; biomaterial evaluation; composite resins; dental adhesive /sealant; dental materials

Recognizing the need to develop new and improved dental adhesives and new long-lasting restorative materials, this proposal requests funds to establish an interdisciplinary materials science program project. The goals for the program project include: develop adhesives that will protect exposed dentin and the underlying pulp; assess the mechanical, physical, and biocompatibility properties of the newly developed adhesives and composite materials; develop and apply surface analysis techniques and promote collaboration between basic scientists. In order to accomplish these goals, over thirty scientists from the University of Missouri/Kansas City, Midwest Research Institute, and Surfaces Research and Applications have joined together as investigators. In addition, outside scientific experts will serve as technical advisors and will provide an interface with the scientific community and dental industry. The administrative scientific support personnel will consist of a director and co-director; administrative personnel; an internal review board; academicians who will provide academic support as research mentors; statistical support consultants and outside scientific consultants. The administrative support service also consists of three core activities which provide testing service for the subprojects. Statistical support, surface analysis and biocompatibility testing are included in the core activities. Three currently funded subprojects and three new proposed subprojects will constitute the major research effort. The four new subprojects will include the development of copolymer dental adhesive systems, development of improved coatings for composite fillers, development and application of surface analysis techniques, and biocompatibility test development and performance. Currently funded research includes characterization of dentin as a substrate for adhesion, development of nonshrinking matrix polymers, and investigation of multifunctional monomer adhesives. Through the combination of these efforts major goals of the program project should be accomplished, and the dental profession should benefit through the development of new biomaterials.

认识到需要开发新的和改进的牙科粘合剂和新的 持久的修复材料，该提案要求提供资金 建立跨学科材料科学计划项目。 这 该计划项目的目标包括： 开发能够保护的粘合剂 暴露的牙本质和下面的牙髓；评估机械、物理、 新开发的粘合剂和生物相容性 复合材料；开发和应用表面分析技术以及 促进基础科学家之间的合作。 为了实现 这些目标，来自密苏里/堪萨斯大学的三十多名科学家 城市、中西部研究所和表面研究与应用 已作为调查员联合起来。 此外，科学之外 专家将担任技术顾问，并提供与 科学界和牙科行业。 行政方面 科学支持人员将由一名主任和副主任组成； 行政人员；内部审查委员会；院士们将 作为研究导师提供学术支持；统计支持 顾问和外部科学顾问。 行政支持 服务还包括提供测试的三个核心活动 为子项目服务。 统计支持、表面分析和 生物相容性测试包含在核心活动中。 三 目前资助的子项目和三个新提议的子项目将 构成了主要的研究工作。 这四个新子项目将 包括共聚物牙科粘合剂系统的开发、 复合填料改良涂料的研究、开发及应用 表面分析技术和生物相容性测试开发和 表现。 目前资助的研究包括牙本质的表征 作为粘合基材，开发非收缩基质聚合物， 多功能单体粘合剂的研究。 通过 将这些努力结合起来，该计划项目的主要目标应该是 牙科行业应该从以下方面受益： 新型生物材料的开发。