IMPROVED POLYMERIC RESTORATIVE THROUGH MOLECULAR DESIGN

认识到需要开发新的和改进的牙科粘合剂和新的 持久的修复材料，该提案要求资金， 建立跨学科的材料科学计划项目。 的 该计划项目的目标包括：开发粘合剂， 暴露的牙本质和下面的牙髓;评估机械，物理， 新开发的粘合剂的生物相容性， 复合材料;发展和应用表面分析技术， 促进基础科学家之间的合作。 为了实现 为了实现这些目标，来自密苏里州/堪萨斯大学的30多位科学家 城市，中西部研究所，表面研究和应用 联合起来作为调查员。 除此之外，科学 专家将担任技术顾问，并将提供一个接口， 科学界和牙科行业。 行政 科学支助人员将包括一名主任和一名副主任; 行政人员;内部审查委员会;院士谁将 作为研究导师提供学术支持;统计支持 顾问和外部科学顾问。 行政支助 服务还包括三个核心活动， 为子项目服务。 统计支持、表面分析和 生物相容性试验包括在核心活动中。 三 目前资助的次级项目和三个新的拟议次级项目将 这是主要的研究工作。 四个新的次级项目将 包括共聚物牙科粘合剂系统的开发， 复合填料用涂料的改进， 表面分析技术和生物相容性试验开发， 性能 目前资助的研究包括表征牙本质 作为用于粘合的基底，形成不收缩的基质聚合物， 以及多功能单体粘合剂的研究。 通过 结合这些努力，项目的主要目标应该是 完成，牙科专业应该受益于 开发新的生物材料。

Recognizing the need to develop new and improved dental adhesives and new long-lasting restorative materials, this proposal requests funds to establish an interdisciplinary materials science program project. The goals for the program project include: develop adhesives that will protect exposed dentin and the underlying pulp; assess the mechanical, physical, and biocompatibility properties of the newly developed adhesives and composite materials; develop and apply surface analysis techniques and promote collaboration between basic scientists. In order to accomplish these goals, over thirty scientists from the University of Missouri/Kansas City, Midwest Research Institute, and Surfaces Research and Applications have joined together as investigators. In addition, outside scientific experts will serve as technical advisors and will provide an interface with the scientific community and dental industry. The administrative scientific support personnel will consist of a director and co-director; administrative personnel; an internal review board; academicians who will provide academic support as research mentors; statistical support consultants and outside scientific consultants. The administrative support service also consists of three core activities which provide testing service for the subprojects. Statistical support, surface analysis and biocompatibility testing are included in the core activities. Three currently funded subprojects and three new proposed subprojects will constitute the major research effort. The four new subprojects will include the development of copolymer dental adhesive systems, development of improved coatings for composite fillers, development and application of surface analysis techniques, and biocompatibility test development and performance. Currently funded research includes characterization of dentin as a substrate for adhesion, development of nonshrinking matrix polymers, and investigation of multifunctional monomer adhesives. Through the combination of these efforts major goals of the program project should be accomplished, and the dental profession should benefit through the development of new biomaterials.