MECHANISMS OF OROFACIAL NOCICEPTION AND THERMORECEPTION

口面部伤害和热感受的机制

• 批准号: 2129077
• 负责人: JONATHAN O DOSTROVSKY
• 金额: $ 9.2万
• 依托单位: UNIVERSITY OF TORONTO
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-07-01 至 1997-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2129077
• 关键词: cats; cold temperature; dorsal horn; electrophysiology; heat stimulus; laboratory rat; neuroanatomy; oral facial pain; sensory feedback; sensory mechanism; spinal trigeminal nucleus; thalamus; thermoreception; thermoreceptors

DESCRIPTION: The general goals of this project are to elucidate the central mechanisms underlying thermoreception and nociception. The specific aims of the proposed project are to determine the response properties of thermoreceptive neurons in the trigeminal brainstem complex and thalamus and their projection targets as well as to examine the interaction of thermoreceptive afferent inputs on the responses of nociceptive neurons. Electrophysiological extracellular single unitrecording techniques will be employed in anesthetized rats and cats. Recordings will concentrate on neurons located in the marginal layer of the medullary dorsal horn (MDH) although the possible existence of thermoreceptive neurons in deeper layers of the MDH and in trigeminal subnucleus interpolaris will also be examined. The responses of thermoreceptive neurons to innocuous and noxious cold and hot stimuli will be characterized. The projection targets of these neurons in thalamus will be determined by means of antidromic mapping techniques. The influence of descending influences from cortex and brainstem will be ascertained. Other experiments will examined the effects of skin cooling on the responses of nociceptive neurons in the MDH. In the second part of the project recordings will be made in thalamus of cats and rats and the responses and locations of thalamic thermoreceptive neurons characterized. These experiments will provide new data on the processing of temperature information in the trigeminal spinal tract nucleus and thalamus and clarify the mechanisms underlying cold pain. They will also examine the interactions of thermal cutaneous inputs with nociceptive inputs and may provide new insights on the central processing of nociceptive information.

描述：这个项目的总体目标是阐明 热感受和伤害感的中枢机制。这个 拟议项目的具体目标是确定回应 三叉神经脑干感热神经元的特性 复合体和丘脑及其投射靶点以及 检查热感受性传入输入对 伤害性神经元的反应。电生理胞外 单单位记录技术将用于麻醉大鼠和 猫。录音将集中在位于边缘的神经元 延髓背角层(MDH)尽管可能存在 MDH深层和下丘脑中的感热神经元 三叉神经内侧亚核也将被检查。回应： 热感受性神经元对无害和有害冷热刺激的反应 将被描述为。这些神经元在脑内的投射靶点 丘脑将通过逆行标测的方法来确定 技巧。大脑皮层和大脑皮层的下行影响 脑干将被确定。其他实验将检验 皮肤降温对大脑皮层伤害性神经元反应的影响 MDH。在项目的第二部分，录音将在 猫和大鼠丘脑及丘脑的反应和定位 热感受性神经元的特征。这些实验将提供 三叉神经体温信息处理的新数据 脊髓束核和丘脑，并阐明潜在的机制 冰冷的疼痛。他们还将研究热的相互作用 具有伤害性输入的皮肤输入，并可能提供新的见解 关于伤害性信息的中央处理。