NEURAL MECHANISMS OF NOCICEPTION IN THE FACE AND MOUTH

面部和口腔伤害感受的神经机制

• 批准号: 3219402
• 负责人: JONATHAN O DOSTROVSKY
• 金额: $ 5.96万
• 依托单位: UNIVERSITY OF TORONTO
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-07-01 至 1993-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3219402
• 关键词: afferent nerve; brain stem; cats; caudate nucleus; central neural pathway /tract; cerebral cortex; electrophysiology; laboratory rat; neural information processing; neuroanatomy; neurophysiology; oral facial pain; pain; spinal trigeminal nucleus; thalamocortical tract; thalamus; vascular smooth muscle nervous control

The overall aim of these studies is to increase our understanding of the neural mechanisms involved in mediating the perception of pain. The specific aim of the proposed studies over the next 3 years is to extend our successful studies initiated during the current granting period on (1) the function of the pathway ascending from subnucleus caudalis (SNC) of the brainstem trigeminal (V) nucleus to ventrolateral orbital cortex (VLO) via a relay in nucleus submedius (Sm) in medial thalamus and (2) the characteristics of neurons in the V system activated by sensory stimulation of cerebral blood vessels. Recent anatomical studies have described a pathway originating in the marginal layer of SNC. relaying in Sm and terminating in VLO. Indirect evidence strongly suggests that this pathway is involved specifically in the processing and relay of pain signals. No physiological studies apart from our own have addressed this potentially very important pathway. In addition, virtually nothing is known concerning the sensory receptors associated with the cranial blood vessels. These V afferents are believed to mediate vascular head pains such as migraine and thus it is of scientific and clinical importance to determine their physiological properties. The studies will be carried out in anesthetized rats and cats and employ primarily single cell electrophysiological recording techniques. The studies will characterize the functional properties of neurons in SNC that project to Sm, as well as neurons in Sm and VLO. Other experiments will be devoted to investigating in greater detail the types of peripheral stimuli and chemical agents which activate and influence the sensitivity of the sensory afferents innervating the cerebral vasculature. Some of these latter studies will be conducted in the rat where in addition to recordings from SNC neurons, recordings will be obtained from V ganglion neurons in order to determine the functional characteristics of the sensory fibers innervating the intracerebral vessels. The findings of these various experiments will help provide a clearer explanation of the processes underlying the perception of acute and chronic pain and will help explain the etiology of vascular headaches. In addition, the results may lead to the development of improved clinical methods for the control of pain.

这些研究的总体目标是增加我们的理解 涉及介导感知的神经机制 疼痛。 未来 3 年拟议研究的具体目标 年是为了扩展我们在 (1) 途径功能的当前授权期限 从脑干尾亚核（SNC）上升 三叉神经 (V) 核通过 腹外侧眶皮层 (VLO) 内侧丘脑中下核 (Sm) 的中继，以及 (2) 感觉激活的 V 系统神经元的特征 刺激脑血管。 最近的解剖学研究 描述了一条起源于 SNC 边缘层的途径。 在 Sm 中中继并在 VLO 中终止。 间接证据有力 表明该途径专门参与 疼痛信号的处理和传递。 没有生理学研究 除了我们自己已经解决了这个可能非常重要的问题 途径。 此外，关于这一点，人们几乎一无所知。 与颅血管相关的感觉受体。 这些 V 传入神经被认为可以介导血管性头痛，例如 偏头痛，因此具有科学和临床意义 确定它们的生理特性。 这些研究将是 在麻醉的老鼠和猫身上进行，主要采用 单细胞电生理记录技术。 研究 将表征 SNC 中神经元的功能特性 投射到 Sm 以及 Sm 和 VLO 中的神经元。 其他实验 将致力于更详细地调查 周围刺激和化学试剂激活和影响 支配大脑的感觉传入的敏感性 脉管系统。 后面的一些研究将在 大鼠除了 SNC 神经元的记录外，还记录 将从 V 神经节神经元获得以确定 支配感觉纤维的功能特征 脑内血管。 这些不同实验的结果 将有助于对底层流程提供更清晰的解释 对急性和慢性疼痛的感知，将有助于解释 血管性头痛的病因学。 此外，结果可能会导致 开发改进的临床方法来控制 疼痛。