Saving your skin: physiology of immune regulation in mammalian lymph nodes

拯救你的皮肤：哺乳动物淋巴结免疫调节的生理学

• 批准号: DP200102011
• 负责人: A/Prof James Wells
• 金额: $ 34.05万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200102011
• 关键词: Saving; your; skin; physiology; immune

The overall aim of this proposal is to understand the mechanisms through which a rare population of regulatory cells maintains skin integrity. Despite their importance, little is known about the regulatory pathways these cells utilise. Previous work from the team has described an innovative technique to enrich these cells for in-depth study and demonstrated their potent regulatory capacity in vivo. This project will enhance our understanding of these cells and uncover their mechanisms of action. The outcomes of this work will therefore provide fundamental new knowledge of skin physiology, and lead to novel insights regarding how healthy skin, which is essential for the very survival and function of a living organism, may be maintained.

这项建议的总体目标是了解通过这种罕见的调节细胞群体维持皮肤完整性的机制。尽管它们很重要，但人们对这些细胞利用的调节途径知之甚少。该团队之前的工作描述了一种创新技术来丰富这些细胞以进行深入研究，并证明了它们在体内的强大调节能力。这个项目将增强我们对这些细胞的理解，并揭示它们的作用机制。因此，这项工作的结果将提供皮肤生理学的基本新知识，并导致关于健康皮肤如何维持的新见解，这对生物体的生存和功能至关重要。