PROLACTIN REGULATION OF PROSTATE CITRATE PRODUCTION

我们的主要目标是阐明和理解的机制， 前列腺的独特功能是 并分泌大量的柠檬酸 特别 重要的是阐明激素在调节 前列腺柠檬酸盐生成。 在人类中，前列腺肿瘤构成 良性前列腺增生是男性中最常见的肿瘤性疾病。 前列腺肥大和前列腺癌的特征是 产生柠檬酸盐的能力的改变。 这些研究将导致 最终理解正常前列腺的转化 细胞到肿瘤细胞，并可能提供一个合理的方法， 在这些肿瘤的管理中使用与肿瘤相关的药物。 本项目的重点是催乳素在调节 大鼠侧前列腺的柠檬酸盐产生。 前列腺外侧 与人类前列腺的侧叶同源 研究 将阐明催乳素对柠檬酸盐合成和柠檬酸盐 氧化，以及催乳素调节柠檬酸盐的机制 生产 该计划将阐明之间的相互作用 前列腺中的催乳素-柠檬酸锌氧化。 研究还将 确定催乳素调节基因作用的机制 与柠檬酸合成有关。 与猪的比较研究 将进行前列腺检查， 这些关系可能适用于人类前列腺。

Our broad objectives are to elucidate and to understand the mechanism by which the prostate gland performs the unique function of accumulating and secreting extraordinarily high levels of citric acid. Of particular importance is elucidation of the role of hormones in the regulation of prostate citrate production. In humans, prostatic neoplasms constitute the most prevalent neoplastic disease in man. Benign prostatic hypertrophy and prostatic carcinoma are characterized by major alterations in the ability to produce citrate. These studies will lead to the eventual understanding of the transformation of normal prostate cells to neoplastic cells and might provide a rational approach to the use of hormonal-related agents in the management of these neoplasms. This project focuses on the role of prolactin in the regulation of citrate production by lateral prostate of the rat. The lateral prostate is homologous to the lateral lobe of the human prostate. The studies will elucidate the effect of prolactin on citrate synthesis and citrate oxidation, and the mechanisms by which prolactin regulates citrate production. The program will elucidate the interaction among prolactin-zinc-citrate oxidation in prostate. Studies will also determine the mechanism by which prolactin regulates gene action associated with citrate synthesis. A comparative study with pig prostate will be conducted which will provide corroborating evidence that these relationships are likely applicable to human prostate.