Cellular and molecular mechanisms shaping animal tissue architecture

塑造动物组织结构的细胞和分子机制

• 批准号: 183749-2009
• 负责人: Tepass, Ulrich
• 金额: $ 2.7万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=498133
• 关键词: Cellular; molecular; mechanisms; shaping; animal

Animal morphogenesis is a fascinating and challenging area of modern biology. Many of the mechanisms that regulate cell and tissue shape are still poorly understood although abnormal morphogenesis is the cause of many human diseases. We use the fruit fly as a powerful genetic model system and we have studied several aspects of the development of the Drosophila eye to understand the formation of the architecture of complex cells and tissues. We will continue our work on the formation of the interrhabdomeral space, an epithelial lumen that is found at the centre of every ommatidium of the compound eye of a fly. Many organs contain tubes where epithelial cells surround a central lumen. Examples include lungs, liver, kidneys or the vascular system. Not only the formation and maintenance, but also the regulation of lumen shape (e.g. its diameter), are important determinants of organ function.

动物形态发生是现代生物学中一个迷人而富有挑战性的领域。许多调节细胞和组织形状的机制仍然知之甚少，尽管异常的形态发生是许多人类疾病的原因。我们使用果蝇作为一个强大的遗传模型系统，我们研究了果蝇眼睛发育的几个方面，以了解复杂细胞和组织结构的形成。我们将继续研究横纹肌间隙的形成，横纹肌间隙是一种上皮腔，位于苍蝇复眼的每个小眼的中心。许多器官都有导管，上皮细胞围绕着中心管腔。例子包括肺、肝、肾或血管系统。不仅是形成和维持，而且管腔形状（如直径）的调节是器官功能的重要决定因素。