PHARYNGEAL/UPPER ESOPHAGEAL SPHINCTER PRESSURE DYNAMICS

咽/食管上括约肌压力动态

• 批准号: 2145417
• 负责人: DONALD O CASTELL
• 金额: $ 22.75万
• 依托单位: GRADUATE HOSPITAL (PHILADELPHIA)
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 1996-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2145417
• 关键词: esophagus motility /pressure; gastrointestinal disorder diagnosis; human old age (65+); human subject; nervous system disorder; neuromuscular disorder; pharynxs; radiography; swallowing

DESCRIPTION (adapted from investigator's abstract and/or aims): The long term objective of this project is to determine the value of a quantitative assessment of the upper esophageal sphincter/pharyngeal (UES/P) pressure dynamics in the diagnosis and prognosis of therapy in conditions leading to pharyngeal dysphagia. In order to accomplish this, it will be necessary to first determine these pressure dynamics in normal volunteers. Since many patients suffering from pharyngeal dysphagia are elderly, an assessment of the changes in these dynamics that are a consequence of normal aging will be made. The effects of various postures and types of foods will also be studied. Quantitative assessment of abnormal UES/P dynamics related to neurologic and neuromuscular disorders will be made prior to therapeutic intervention and during treatment. Changes in pressure dynamics will be correlated with clinical response and a predictive model for therapeutic response will be built. UES/P manometry will be performed first in normal volunteers, with a particular emphasis on subjects older than 60 years, using a specially designed catheter to compensate for anatomical difficulties. Patients with a variety of neurologic and neuromuscular disorders will also be studied manometrically. Manometry data will be collected on-line using a computer and an analog to digital converter. Manometric parameters will be determined automatically, using computer generated algorithms. In addition, patients will be studied radiographically with a combination of static and motion images recorded on videotape. Patients will be evaluated by neurologist using a clinical assessment scale appropriate to the disease. A speech-language pathologist will determine the degree and severity of functional dysphagia. All clinicians will be blinded to the manometric results. This multidisciplinary approach will provide several independent scales to determine the severity of the disorder and increase the probability of relating manometric measures to an effect of the disease.

描述（改编自研究者的摘要和/或目的）： 本项目的长期目标是确定一个定量的价值 上食管括约肌/咽部（UES/P）压力评估 在诊断和治疗预后中的动力学， 咽部吞咽困难 为了做到这一点，有必要 首先确定正常志愿者的压力动态。 由于许多 患有咽部吞咽困难的患者是老年人， 这些动力学的变化是正常衰老的结果， 被制造。 各种姿势和食物类型的影响也将 研究了 定量评估与下列因素相关的异常UES/P动态 神经和神经肌肉疾病将在治疗前进行 干预和治疗期间。 压力动态的变化将是 与临床反应和治疗的预测模型相关 将建立响应。 首先在正常志愿者中进行UES/P测压， 特别强调60岁以上的受试者， 设计导管以补偿解剖学困难。 患者 还将研究各种神经和神经肌肉疾病 压力测量的。 将使用计算机在线收集测压数据 和模数转换器。 测压参数将为 使用计算机生成的算法自动确定。 在 此外，将对患者进行放射学研究， 录像带上记录的静态和动态图像。 将评价患者 由神经科医生使用适用于 疾病 语言病理学家将确定程度和 功能性吞咽困难的严重程度。 所有临床医生将对以下内容设盲： 测压结果。 这种多学科的方法将提供几个 独立的量表来确定疾病的严重程度， 将测压措施与 疾病