ESOPHAGEAL MANOMETRIC ABNORMALITIES AND CHEST PAIN

这项研究将评估食道异常在 复发性胸痛的患者被记录为非心脏的 起源。这项研究将试图评估发病率和原因。 食道动力异常与胸痛的关系 食道疼痛产生的一些可能机制。初步研究 将评估100名正常人的食道动力发现范围 所有年龄段的受试者都能更好地定义“异常”反应。vbl.使用 这些标准，将寻找食道运动异常的证据 一大群患有“非心源性”胸痛的患者 有已知心脏异常的患者。长时间使用的器械 至72小时)监测食道内压力和pH值 用于确定特定的食道动力异常 可能与这些患者的胸痛事件相关。一种系统，用于 直接在线计算机评估食道运动的结果将是 为更快速、更客观地评估测压结果而开发。 食管性胸痛患者的长期随访 将通过建立胸痛诊所获得。 食道疼痛产生的机制(S)将通过一个 方法的数量。既有的挑衅方法的影响 食道胸痛将在持续测压期间进行评估 在上面讨论的患者组中进行监测。这些技术将 包括向食道内输酸和静脉注射 依德罗芬铵。将对远端食道球囊扩张进行评估。 在正常志愿者和食道运动患者组中 异常现象。因为可能的情感和压力关系 由食道引起的胸痛，个性特征和运动能力 将评估这些患者对诱导应激的反应。

This study will evaluate the importance of esophageal abnormalities in patients with recurring chest pain documented to be "non-cardiac" in origin. The study will attempt to evaluate both the incidence and causal relationship of esophageal motility abnormalities to chest pain and also some possible mechanisms of esophageal pain production. Initial studies will evaluate the range of esophageal motility findings in 100 normal subjects in all age groups to better define the "abnormal" response. Using these criteria, evidence for abnormal esophageal motility will be sought in a large group of patients with "non-cardiac" chest pain and also in patients with known cardiac abnormalities. An apparatus for prolonged (up to 72 hours) monitoring of intraesophageal pressure and pH will be developed to ascertain whether specific esophageal motility abnormalities can be correlated with chest pain events in these patients. A system for direct on-line computer evaluation of esophageal motility findings will be developed for more rapid and objective evaluation of manometric findings. Long term follow-up of patients identified as having esophageal chest pain will be obtained through the establishment of a chest pain clinic. The mechanism(s) of esophageal pain production will be studied through a number of approaches. The effects of established methods of provoking esophageal chest pain will be evaluated during constant manometric monitoring in the patient groups discussed above. These techniques will include both acid infusion into the esophagus and intravenous injections of edrophonium. Balloon distention in the distal esophagus will be evaluated in normal volunteers and in groups of patients with esophageal motility abnormalities. Because of the possible emotional and stress relationship of chest pain produced by the esophagus, personality profiles and motility response to induced stress will be evaluated in these patients.