PHARYNGEAL/UPPER ESOPHAGEAL SPHINCTER PRESSURE DYNAMICS

描述(改编自调查员的摘要和/或目标)：长篇 本项目的学期目标是确定一个量化的价值 上食道括约肌/咽(UES/P)压力的评估 动力学在诊断和治疗预后中的作用 咽部吞咽困难。为了实现这一点，有必要 首先确定正常志愿者的这些压力动态。因为有很多人 咽部吞咽困难患者为老年人，一项评估 作为正常衰老的结果，这些动态的变化将 被创造出来。各种姿势和类型的食物的影响也将是 学习。与UES/P相关的异常动力学的定量评估 神经和神经肌肉疾病将在治疗前进行 干预和治疗期间。压力动态的变化将是 与临床疗效的相关性和治疗预测模型 我们将会做出回应。 将首先在正常志愿者中进行UE/P测压，并进行 特别强调60岁以上的受试者，使用特别的 为弥补解剖困难而设计的导管。患有疾病的患者 此外，还将研究各种神经学和神经肌肉疾病。 测压法。测压数据将使用计算机在线收集 以及模数转换器。测压参数将为 使用计算机生成的算法自动确定。在……里面 此外，将对患者进行放射学研究，结合使用 录像带上记录的静态和动态图像。将对患者进行评估 由神经科医生使用适合于 疾病。言语语言病理学家将确定程度和 功能性吞咽困难的严重程度。所有临床医生都将被蒙在鼓里 测压结果。这种多学科的方法将提供几个 独立的量表，以确定疾病的严重程度和增加 将测压措施与压力影响相关联的概率 疾病。

DESCRIPTION (adapted from investigator's abstract and/or aims): The long term objective of this project is to determine the value of a quantitative assessment of the upper esophageal sphincter/pharyngeal (UES/P) pressure dynamics in the diagnosis and prognosis of therapy in conditions leading to pharyngeal dysphagia. In order to accomplish this, it will be necessary to first determine these pressure dynamics in normal volunteers. Since many patients suffering from pharyngeal dysphagia are elderly, an assessment of the changes in these dynamics that are a consequence of normal aging will be made. The effects of various postures and types of foods will also be studied. Quantitative assessment of abnormal UES/P dynamics related to neurologic and neuromuscular disorders will be made prior to therapeutic intervention and during treatment. Changes in pressure dynamics will be correlated with clinical response and a predictive model for therapeutic response will be built. UES/P manometry will be performed first in normal volunteers, with a particular emphasis on subjects older than 60 years, using a specially designed catheter to compensate for anatomical difficulties. Patients with a variety of neurologic and neuromuscular disorders will also be studied manometrically. Manometry data will be collected on-line using a computer and an analog to digital converter. Manometric parameters will be determined automatically, using computer generated algorithms. In addition, patients will be studied radiographically with a combination of static and motion images recorded on videotape. Patients will be evaluated by neurologist using a clinical assessment scale appropriate to the disease. A speech-language pathologist will determine the degree and severity of functional dysphagia. All clinicians will be blinded to the manometric results. This multidisciplinary approach will provide several independent scales to determine the severity of the disorder and increase the probability of relating manometric measures to an effect of the disease.