PHARYNGEAL/UPPER ESOPHAGEAL SPHINCTER PRESSURE DYNAMICS

咽/食管上括约肌压力动态

• 批准号: 3247696
• 负责人: DONALD O CASTELL
• 金额: $ 21.65万
• 依托单位: GRADUATE HOSPITAL (PHILADELPHIA)
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 1996-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3247696
• 关键词: esophagus motility /pressure; gastrointestinal disorder diagnosis; human old age (65+); human subject; nervous system disorder; neuromuscular disorder; pharynxs; radiography; swallowing

DESCRIPTION (adapted from investigator's abstract and/or aims): The long term objective of this project is to determine the value of a quantitative assessment of the upper esophageal sphincter/pharyngeal (UES/P) pressure dynamics in the diagnosis and prognosis of therapy in conditions leading to pharyngeal dysphagia. In order to accomplish this, it will be necessary to first determine these pressure dynamics in normal volunteers. Since many patients suffering from pharyngeal dysphagia are elderly, an assessment of the changes in these dynamics that are a consequence of normal aging will be made. The effects of various postures and types of foods will also be studied. Quantitative assessment of abnormal UES/P dynamics related to neurologic and neuromuscular disorders will be made prior to therapeutic intervention and during treatment. Changes in pressure dynamics will be correlated with clinical response and a predictive model for therapeutic response will be built. UES/P manometry will be performed first in normal volunteers, with a particular emphasis on subjects older than 60 years, using a specially designed catheter to compensate for anatomical difficulties. Patients with a variety of neurologic and neuromuscular disorders will also be studied manometrically. Manometry data will be collected on-line using a computer and an analog to digital converter. Manometric parameters will be determined automatically, using computer generated algorithms. In addition, patients will be studied radiographically with a combination of static and motion images recorded on videotape. Patients will be evaluated by neurologist using a clinical assessment scale appropriate to the disease. A speech-language pathologist will determine the degree and severity of functional dysphagia. All clinicians will be blinded to the manometric results. This multidisciplinary approach will provide several independent scales to determine the severity of the disorder and increase the probability of relating manometric measures to an effect of the disease.

描述（改编自研究者的摘要和/或目标）：长篇 该项目的长期目标是确定定量的价值 评估上食管括约肌/咽部 (UES/P) 压力 导致病情的诊断和治疗预后的动态 咽部吞咽困难。 为了实现这一目标，有必要 首先确定正常志愿者的这些压力动态。 由于许多 患有咽部吞咽困难的患者年龄较大，评估 由于正常衰老而导致的这些动态的变化将 被制作。 各种姿势和食物类型的影响也会 研究过。 与以下相关的异常 UES/P 动态的定量评估 神经系统和神经肌肉疾病将在治疗前进行 干预和治疗期间。 压力动态的变化将是 与临床反应和治疗预测模型相关 将建立响应。 UES/P 测压将首先在正常志愿者中进行， 特别强调 60 岁以上的受试者，使用专门的 设计导管以弥补解剖学上的困难。 患者患有 还将研究各种神经系统和神经肌肉疾病 压力测量。 将使用计算机在线收集测压数据 和一个模数转换器。 测压参数将是 使用计算机生成的算法自动确定。 在 此外，还将结合以下方法对患者进行放射学研究 录制在录像带上的静态和动态图像。 患者将接受评估 由神经科医生使用适合的临床评估量表 疾病。 言语病理学家将确定程度和 功能性吞咽困难的严重程度。 所有临床医生都将被蒙蔽 测压结果。 这种多学科方法将提供多种 独立量表来确定疾病的严重程度并增加 将测压措施与效果相关的概率 疾病。