Cost Effective Dual Laser System for Nonlinear CARS Microscopy

用于非线性 CARS 显微镜的经济高效的双激光系统

• 批准号: 130853
• 金额: $ 3.15万
• 依托单位: SOLUS TECHNOLOGIES LTD
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=130853
• 关键词: Cost; Effective; Dual; Laser; System

Biomedical research is a large high value market and fluorescence microscopy are some of the most common and powerful tools used. Fluorescence imaging techniques require the region to be studied to be labelled with a dye, this often disrupts cell function and any typically releases toxins. In contrast Coherent anti-Stokes Raman Scattering (CARS) microscopy enables the researcher to harness the high 3D resolution capability of nonlinear microscopy while avoiding the photo-toxicity issue. In addition it can provide molecule specific information. CARS has found diverse applications in biology, and it is employed in DNA analysis and cancer detection. The primary aim of the study is to look at the feasibility of using two pulsed SDL lasers operating at dissimilar wavelengths for use in a CARS microscope.

生物医学研究是一个巨大的高价值市场，荧光显微镜是最常用和最强大的工具之一。荧光成像技术需要用染料标记要研究的区域，这通常会破坏细胞功能，并且通常会释放毒素。相比之下，相干反斯托克斯拉曼散射 (CARS) 显微镜使研究人员能够利用非线性显微镜的高 3D 分辨率能力，同时避免光毒性问题。此外，它还可以提供分子特定信息。 CARS 在生物学中有着多种应用，例如 DNA 分析和癌症检测。该研究的主要目的是探讨在 CARS 显微镜中使用两个以不同波长工作的脉冲 SDL 激光器的可行性。