Precision-engineered hybrid core-shell materials

精密设计的混合核壳材料

• 批准号: DP200101238
• 负责人: Prof Chun-Xia Zhao
• 金额: $ 30.83万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-06-19 至 2024-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200101238
• 关键词: Precision; engineered; hybrid; core; shell

This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipitation platform technology for making drug-core polymer-shell nanoparticles, and a new bio-inspired approach for making hybrid drug-core silica-shell nanocomposites, and new materials for applications in programmed release and delivery systems.

该项目旨在开发新的平台技术，用于制造具有极高载药量和程序释放的纳米结构混合核壳材料。基于该研究团队最近在核壳材料精密工程方面的突破，这项研究将彻底改变目前制造载药聚合物和无机颗粒的方法。重大成果将包括一种新的连续纳米沉淀平台技术，用于制造药物核聚合物壳纳米颗粒，以及一种新的生物启发方法，用于制造混合药物核二氧化硅壳纳米复合材料，以及用于程序释放和递送系统的新材料。