Platform technologies for multifunctional nanocarrier systems

多功能纳米载体系统的平台技术

• 批准号: FT140100726
• 负责人: Prof Chun-Xia Zhao
• 金额: $ 53.18万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2020-06-18
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT140100726
• 关键词: Platform; technologies; multifunctional; nanocarrier; systems

Smart targeted nanocarriers offer new opportunities for drug delivery. This project aims to develop new platforms for reproducibly producing and screening targeted nanocarriers. The platform technologies developed in this project aim to revolutionise current strategies for designing and evaluating drug delivery systems, and will accelerate the clinical translation of targeted drug delivery. This will include a novel one-step microfluidic platform technology for reproducibly producing targeted polymer nanocarriers having systematically varied properties, a dual-templating method for making targeted silica nanocapsules and new design of in vivo-mimicking 'Tissue Chips' for screening and evaluating the nanocarriers.

智能靶向纳米载体为药物递送提供了新的机会。该项目旨在开发可重复生产和筛选靶向纳米载体的新平台。该项目开发的平台技术旨在彻底改变当前设计和评估药物输送系统的策略，并将加速靶向药物输送的临床转化。这将包括一种新的一步微流控平台技术，用于可重复地生产具有系统变化特性的靶向聚合物纳米载体，一种用于制造靶向二氧化硅纳米胶囊的双模板方法，以及用于筛选和评估纳米载体的体内模拟“组织芯片”的新设计。