Understanding how an old heart gets stiff

了解一颗年老的心是如何变得僵硬的

• 批准号: DP200101152
• 负责人: Dr Melissa Reichelt
• 金额: $ 30.87万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-02-28 至 2023-02-27
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200101152
• 关键词: Understanding; how; old; heart; gets

Aging is accompanied by a stiffening of the heart and reduced function, which is accelerated by cardiovascular disease and leads to heart failure. How the heart stiffens is poorly understood. A new mechanism is proposed here, involving structural membrane proteins (termed caveolae and cavins) and a signalling molecule (nitric oxide). The current research aims to unravel the interplay between cardiac cells and these proteins/signals to cause stiffness and to determine whether this process governs normal aging of the heart. This work will advance understanding of how heart function is determined and reveal how the human heart changes with normal aging.

衰老伴随着心脏僵硬和功能下降，心血管疾病加速了这一过程，并导致心力衰竭。人们对心脏是如何变硬的还知之甚少。本文提出了一种新的机制，涉及结构膜蛋白（称为caveolae和cavins）和信号分子（一氧化氮）。目前的研究旨在揭示心肌细胞和这些蛋白质/信号之间的相互作用，以导致僵硬，并确定这一过程是否控制心脏的正常衰老。这项工作将促进对心脏功能如何决定的理解，并揭示人类心脏如何随着正常衰老而变化。