A mechanistic and dyadic approach to identify how interpersonal conscientiousness supports cognitive health and lowers risk of dementia

采用机械和二元方法来确定人际责任感如何支持认知健康并降低痴呆风险

• 批准号: 10739837
• 负责人: Angelina R Sutin
• 金额: $ 230.02万
• 依托单位: FLORIDA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10739837
• 关键词: Achievement; Address; Adult; Affect; Age; Alzheimer' s Disease; Alzheimer' s disease related dementia; Behavior; Behavioral; Clinical; Cognition; Cognitive; Cognitive aging; Communities; Complex; Couples; Dementia; Diabetes Mellitus; Discipline; Disease Progression; Ecological momentary assessment; Environment; Etiology; Family; Genetic; Goals; Health; Healthcare Systems; Hypertension; Impaired cognition; Impairment; Individual; Inflammation; Intervention; Interviewer; Knowledge; Life; Life Cycle Stages; Literature; Loneliness; Longevity; Measures; Mental Depression; Modeling; National Institute on Aging; Nerve Degeneration; Obesity; Onset of illness; Outcome; Pathway interactions; Personal Satisfaction; Personality Traits; Physical activity; Physiological; Prevalence; Prevention; Prevention strategy; Process; Psychological Factors; Public Health; Research; Risk; Risk Behaviors; Risk Factors; Risk Reduction; Sampling; Self-control as a personality trait; Services; Sleep; Smoking; Stress; Testing; Theoretical model; Time; Well in self; Work; cognitive function; cognitive performance; cognitive task; critical period; dementia risk; discounting; effective intervention; healthy aging; human old age (65+); member; middle age; novel; prevent; protective effect; protective factors; psychologic; recruit; satisfaction; therapy development; trait

Project Summary The burden of Alzheimer’s Disease (AD) takes a significant toll on the individual living with dementia, their families and communities, and the healthcare system. Without effective intervention and prevention strategies, the prevalence of AD is expected to more than double over the next 30 years. It is critical to identify protective factors that can be leveraged for more effective prevention before the onset of the disease. Conscientiousness is a personality trait that is associated consistently with better health outcomes, which extends to dementia: Conscientiousness is one of the most replicated psychological factors that is protective against cognitive impairment. Most work on Conscientiousness has focused on its agentic aspects (e.g., self-control, achievement striving). Conscientiousness, however, has a distinct interpersonal component that is often overlooked in the relation with health in general and cognition in particular. This interpersonal component – Interpersonal Conscientiousness – defined as either responsibility or dutifulness, is protective against dementia, an effect that has replicated in three independent samples. In addition, its protective association with dementia is independent of the agentic components of this trait and extends to cognitive function prior to dementia. Interpersonal Conscientiousness is thus a robust and novel psychological factor that is a promising target of intervention for healthier cognitive outcomes in older adulthood. The objective of this proposal is to provide much needed stage 0 evidence that is necessary for intervention development. Specifically, this research aims to identify the clinical/physiological, behavioral, psychological, and relational mechanisms through which Interpersonal Conscientiousness leads to better cognitive outcomes. The proposed research addresses these mechanisms and cognition as typically measured in lab settings and the daily expression of these mechanisms and momentary cognitive performance measured with ecological momentary assessment in everyday life. It seeks to identify the pathways through which Interpersonal Conscientiousness protects cognition and promotes better daily cognitive function across a critical period of the lifespan – midlife and the transition to old age (ages 40-70) – a period particularly relevant for prevention because it is generally before the onset of neurodegeneration. In addition, this research addresses actor and partner effects within committed relationships to test whether the protective effect of Interpersonal Conscientiousness extends from one member of the couple to the other. This work will lead to new knowledge on how Interpersonal Conscientiousness promotes healthier cognitive aging and will point to new prevention and intervention targets for promoting healthier cognitive aging across adulthood to support better outcomes in older adulthood.

项目摘要 阿尔茨海默病（AD）的负担对患有痴呆症的个体造成重大损失，他们的生活方式， 家庭、社区和医疗系统。如果没有有效的干预和预防战略， AD的患病率预计在未来30年内将增加一倍以上。关键是要识别保护性的 这些因素可以用来在疾病发作之前进行更有效的预防。尽责性 是一种与更好的健康结果相关联的人格特征，这延伸到痴呆症： 尽责性是一种最常见的心理因素，它可以防止认知障碍， 损伤大多数关于尽责性的工作都集中在其行为方面（例如，自我控制、成就 奋斗）。然而，尽责性有一个明显的人际关系组成部分，这一部分在研究中常常被忽视。 与一般健康，特别是认知的关系。人际关系- Interpersonal 尽责性--被定义为责任或义务，是预防痴呆症的一种效果， 在三个独立的样本中得到了复制。此外，它与痴呆症的保护性关联是独立的。 这一特征的代理成分，并延伸到认知功能之前，痴呆症。人际 因此，尽责性是一个强大而新颖的心理因素，是一个有希望的干预目标， 更健康的认知结果。这项提案的目的是提供急需的舞台， 0证据是干预发展所必需的。具体而言，本研究旨在确定 临床/生理，行为，心理和关系机制，通过这些机制，人际关系 责任心导致更好的认知结果。拟议的研究涉及这些机制 和认知，通常在实验室环境中测量，这些机制的日常表达， 通过日常生活中的生态瞬时评估来测量瞬时认知表现。它寻求 确定人际责任感保护认知和促进更好的人际关系的途径 在生命的关键时期-中年和向老年过渡（40-70岁）的日常认知功能 - 这是一个与预防特别相关的时期，因为它通常是在神经变性发作之前。在 此外，本研究还探讨了承诺关系中的行为者和伴侣效应，以检验 人际责任感的保护作用从夫妻一方延伸到另一方。这 这项工作将带来关于人际责任感如何促进健康认知老化的新知识 并将指出新的预防和干预目标，以促进整个成年期更健康的认知老化 以支持老年人更好的结果。