Ancestral, conserved and novel mechanisms in marsupial genomic imprinting

有袋动物基因组印记的祖先、保守和新颖机制

• 批准号: DP200101138
• 负责人: Prof Marilyn Renfree
• 金额: $ 72.68万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-07-07 至 2025-07-06
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200101138
• 关键词: Ancestral; conserved; novel; mechanisms; marsupial

Genomic imprinting is the differential expression pattern of some genes depending on whether the gene copy came from the mother or the father. This differential expression is essential for embryonic development and errors lead to disease. To date, most of our knowledge of the control of genomic imprinting comes from the mouse, but much less is known about this process in marsupials. Our comparative approach, using marsupial mammals that are distantly related to mice and humans, aims to clarify how genomic imprinting mechanisms have evolved, which patterns are conserved across mammals, and which vary. Our proposed research aims to provide new approaches and understanding of this fundamental process essential for the continuation of life.

基因组印记是指某些基因的差异表达模式取决于基因拷贝是否来自母亲或父亲。这种差异表达对胚胎发育至关重要，错误会导致疾病。迄今为止，我们对基因组印记控制的大部分知识来自小鼠，但对有袋动物的这一过程知之甚少。我们的比较方法，使用有袋类哺乳动物是远亲的小鼠和人类，旨在澄清基因组印记机制是如何演变的，哪些模式是保守的哺乳动物，哪些不同。我们提出的研究旨在提供新的方法和理解这个对生命延续至关重要的基本过程。