EPIDEMIOLOGY OF LEAD, DIET AND BLOOD PRESSURE

铅、饮食和血压的流行病学

• 批准号: 2154018
• 负责人: Howard Hu
• 金额: $ 34.48万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-02-01 至 1996-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2154018
• 关键词: blood pressure; clinical biomedical equipment; clinical chemistry; diagnosis quality /standard; diet; dietary calcium; dopamine; environmental contamination; epidemiology; fluorescence; hematology; human subject; hypertension; lead poisoning; longitudinal human study; male; nutrition related tag; urinalysis

The main objective of this research is to elucidate the inter-relationships between accumulated lead burden measured by K-X-Ray Fluorescence (K-XRF), blood lead levels, dietary calcium, and blood pressure. Previous studies have shown a positive cross-sectional association between blood lead at low levels experienced by the general population and blood pressure and a negative association between dietary calcium and blood pressure. There have been no studies that have assessed the possibility that accumulated lead burden is more closely associated than blood lead with blood pressure increases, and that lead may confound the relationship between dietary calcium and blood pressure; and no studies on the longitudinal relationship between blood lead levels and blood pressure at multiple points in time. The specific aims are focused on examining the above relationships in the Normative Aging Study (NAS), a group of men who have been followed longitudinally since 1962 and are expected to have accumulated lead burdens from low-level environmental exposures that are similar to those sustained by the general population. In preliminary studies we discuss data on blood lead levels, dietary calcium, and blood pressure in the NAS; a study validating the use of frozen red cells for lead analysis in the NAS; our state-of-the art K-XRF instrument and its precision, accuracy, and calibration; two population studies of K-XRF; and a study of the distribution of lead in cadaveric skeletons. In the research plan we propose to use our K-XRF instrument to measure lead burden in NAS subjects, thaw and analyze frozen red cell samples that are available on each NAS subject from multiple visits since the 1960s, and continue collection of fresh blood leads. This would add to the data already being collected, including dietary information using a semi-quantitative food frequency questionnaire, 24 hour urinary amines, blood pressures, and many other physical exam and laboratory parameters. Finally, we outline our strategy for analysis of the data including specific approaches for the blood lead-blood pressure data at multiple points in time.

本研究的主要目标是阐明相互关系 在通过K-X射线荧光（K-XRF）测量的累积铅负荷之间， 血铅水平、膳食钙和血压。以前的研究 已经显示出血铅水平低， 一般人群的血压水平和 膳食钙与血压之间存在负相关。已经 还没有研究评估铅的积累 负荷比血铅与血压的关系更密切 增加，铅可能会混淆饮食之间的关系， 钙和血压;没有纵向关系的研究 血铅水平和血压之间的联系 具体目标集中在审查上述关系， 规范老化研究（NAS），一组男性谁一直在跟踪 自1962年以来，纵向上， 低水平的环境暴露， 被大众所接受。 在初步研究中，我们讨论了血铅水平、饮食 钙和血压;一项验证使用 用于NAS中铅分析的冷冻红细胞;我们最先进的K-XRF 仪器及其精密度、准确度和校准;两个总体 K-XRF的研究;以及尸体中铅分布的研究 骷髅 在研究计划中，我们提出使用我们的K-XRF仪器测量铅 在NAS受试者中，解冻并分析冷冻红细胞样本， 自20世纪60年代以来，每个NAS受试者的多次访视可用，以及 继续收集新鲜血液。这将增加数据 已经在收集，包括饮食信息， 半定量食物频率问卷，24小时尿胺， 血压以及许多其他体检和实验室参数。 最后，我们概述了我们的数据分析策略，包括 在多个地点采集血铅-血压数据的具体方法 时间点。