GENE METAL INTERACTIONS AND PARKINSON'S DISEASE

基因金属相互作用与帕金森病

• 批准号: 7379229
• 负责人: Howard Hu
• 金额: $ 4.07万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379229
• 关键词: GENE; METAL; INTERACTIONS; PARKINSON; DISEASE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will evaluate 800 PD patients as well as 800 controls matched one to one by age, gender, ethnicity, and geographical region. The two main hypotheses are: (1) Among the cases and controls, higher levels of lead in bone are associated with higher odds of PD case. (2) The effect of bone lead will be highest in individuals with heterozygous or homozygous for HFE gene mutation

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究将评价800例PD患者以及800例对照，按年龄、性别、种族和地理区域一一匹配。两个主要的假设是：（1）在病例组和对照组中，骨铅水平越高，PD发病的几率越高。(2)HFE基因突变杂合子或纯合子个体的骨铅效应最高