Demonstration of a green continuous flow process for the low cost production of biopharmaceuticals

生物制药低成本生产的绿色连续流程示范

• 批准号: 131089
• 金额: $ 3.11万
• 依托单位: SWEDISH BIOMIMETICS 3000® LIMITED
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=131089
• 关键词: Demonstration; green; continuous; flow; process

This project seeks to demonstrate a novel technology with the potential for reducing the financial and environmental cost associated with purifying advanced biopharmaceuticals. Many of the most promising new therapies under development are produced using living cells in large fermenters, and while the raw materials for feeding the cells are comparatively inexpensive, the purification of these complex mixtures is very difficult and frequently accounts for 80% of the cost of manufacturing. It is this resource intensive part of the production process that this project seeks to serve with the demonstration of a new process, thus facilitating the passage of new medicines to the patient at lower cost. The output from this project (the demonstration) will be utilised to form a UK development consortium to take the concept through the R & D stage and to market.

该项目旨在展示一种新技术，该技术具有降低与提纯先进生物制药相关的财务和环境成本的潜力。许多正在开发的最有希望的新疗法是使用大型发酵罐中的活细胞生产的，虽然喂养细胞的原材料相对便宜，但这些复杂混合物的纯化非常困难，往往占制造成本的80%。正是生产过程中的这一资源密集型部分，该项目试图通过展示一种新的工艺来服务于这一部分，从而促进以较低的成本向患者提供新药。这个项目(演示)的成果将被用来组成一个英国开发财团，将这一概念带到研发阶段并推向市场。