Developing new tools for chemical biology

开发化学生物学新工具

• 批准号: DP200100796
• 负责人: Prof Martin Scanlon
• 金额: $ 46.99万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200100796
• 关键词: Developing; new; tools; chemical; biology

We will develop new synthetic strategies to support the development of small molecule chemical probes that bind with high affinity and specificity to a target protein. Such chemical probes are invaluable in elucidating the role of specific proteins in biological pathways. Our novel strategy aims to be rapid, efficient in its use of materials and widely applicable to a range of different protein targets. The core of our approach involves using biophysical binding assays to characterise compounds that are produced on small scale using parallel chemistry. This approach will enable better chemical probes to be developed more rapidly at lower cost than is currently possible.

我们将开发新的合成策略来支持小分子化学探针的开发，这些小分子化学探针与目标蛋白质具有高亲和力和特异性。这种化学探针在阐明特定蛋白质在生物途径中的作用方面是非常有价值的。我们的新策略旨在快速、高效地使用材料，并广泛适用于一系列不同的蛋白质靶标。我们方法的核心是使用生物物理结合分析来表征使用平行化学小规模生产的化合物。这种方法将使更好的化学探针能够以比目前更低的成本更快地开发出来。