BIOACCUMULATION OF ENVIRONMENTAL CARCINOGENS--METHODOLOGY AND CHARACTERIZATION

大量研究的证据支持这样一种理论，即人类癌症和 环境污染可能会导致呼吸道疾病。的确有 癌症高发区和癌症高发区之间的良好相关性 呼吸道疾病和高水平的污染。有人怀疑 即使是中等水平的污染也会增加有害的风险 对健康的影响。大气有机组分的生物检测 颗粒物已显示出诱变和致癌活性。然而，在那里 在试图将特定的健康影响归因于 由于环境、暴露和人口的变化而造成的污染。 一项可能显示人体内环境污染物的研究将 为这一理论提供了直接证据。 这个项目的目的是确定有机污染物是否可以 在脂肪组织中沉积和积聚。分析方法能够 对化合物的广谱检测将首先优化为气体 样品、水样、颗粒样品和脂肪组织。空气和空气 两个地点的水，每个地点都是猴子聚居地，将被 随着时间的推移而表现出来的特征。其中一个地点相对没有污染，而 其他地区的空气和水污染水平也很高。相关性 在样品中发现的化合物与脂肪组织中的化合物之间 这两个地点的猴子的数量可以直接证明环境 化合物可能会影响人类健康。

Evidence from numerous studies support the theory that human cancers and respiratory illnesses can be caused by environmental pollution. There is a good correlation between regions with a high incidence of cancer and respiratory illnesses and high levels of pollution. It is suspect that even moderate levels of pollution can increase the risk of detrimental health effects. Biotesting of the organic fraction of atmospheric particulate has shown mutagenic and carcinogenic activity. However there is much uncertainty in trying to attribute specific health effects to pollution due to variations in environment, exposure and the population. A study which could show environmental pollutants in the human body will lend direct evidence to the theory. The purpose of this project is to determine if organic pollutants can deposit and accumulate in lipid tissues. Analytical methodology capable of detecting a broad spectrum of compounds will first be optimized for gaseous samples, water samples, particulate samples and lipid tissues. The air and water at two locations, each the site of a monkey colony, will be characterized over time. One site is relatively pollution free while the other has significant levels of air and water pollution. Correlation between the compounds found in the samples and those in the lipid tissues of monkeys at both sites could give direct evidence that environmental compounds could affect human health.