Hydrophobin proteins on the fungal frontline

真菌前线的疏水蛋白

• 批准号: DP150104227
• 负责人: Prof Margaret Sunde
• 金额: $ 29.13万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-04-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150104227
• 关键词: Hydrophobin; proteins; fungal; frontline

This project aims to use advanced biophysical techniques to study the role of hydrophobin proteins in three diseases caused by fungi. The specific focus will be on hydrophobins from fungal species that cause severe loss of rice plants, cause invasive growths in humans, and infect the eggs of endangered turtles and result in death of the turtle embryos. Hydrophobins are small fungal proteins that assemble into large biological layers at the boundary between the fungus and the host. This research aims to focus on characterising the structure of the layers, understanding how they form and how they attach to the host tissue. This work may lead to new antifungal strategies aimed at reducing the impact of these devastating fungal infections.

该项目旨在利用先进的生物物理技术研究疏水蛋白在真菌引起的三种疾病中的作用。具体的重点将是来自真菌物种的疏水蛋白，这些疏水蛋白会导致水稻植物的严重损失，导致人类的侵入性生长，感染濒危海龟的卵并导致海龟胚胎死亡。疏水蛋白是小的真菌蛋白质，在真菌和宿主之间的边界组装成大的生物层。这项研究的目的是集中在表征层的结构，了解它们如何形成以及它们如何附着在宿主组织上。这项工作可能会导致新的抗真菌策略，旨在减少这些破坏性真菌感染的影响。