Undermining fungal defences by targeting their functional amyloid armour

通过靶向功能性淀粉样蛋白装甲来破坏真菌防御

• 批准号: DP200102463
• 负责人: Prof Margaret Sunde
• 金额: $ 34.41万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-13 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200102463
• 关键词: Undermining; fungal; defences; targeting; their

This project will determine how a protective protein coating forms on the surface of fungal spores and infectious structures. This coating is comprised of amyloid protein fibrils and is used by fungi to improve efficiency of infection and to avoid detection by the host plant or animal. We have discovered novel small molecules that prevent the fibrils from forming. This project will use these molecules to reveal the details of the fibril assembly mechanism and find the best way to undermine this fungal defence system. This knowledge will enable the development of potent small molecule inhibitors to treat fungal infections that blight crops and harm animals, and the production of new layered biomaterials for nanotechnology applications.

该项目将确定如何在真菌孢子和感染结构的表面形成保护性蛋白质涂层。这种涂层由淀粉样蛋白纤维组成，被真菌用来提高感染效率，并避免被宿主植物或动物发现。我们已经发现了阻止纤维形成的新型小分子。这个项目将使用这些分子来揭示原纤维组装机制的细节，并找到破坏这种真菌防御系统的最佳方法。这一知识将使我们能够开发有效的小分子抑制剂来治疗危害作物和动物的真菌感染，并生产用于纳米技术应用的新型层状生物材料。