Understanding how cells regulate self eating during starvation and stress

了解细胞如何在饥饿和压力下调节自我进食

• 批准号: DP200100347
• 负责人: A/Prof Michael Lazarou
• 金额: $ 31.6万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200100347
• 关键词: Understanding; how; cells; regulate; self

This project aims to investigate how autophagosomes are built during autophagy by using advanced multi-modal imaging and unique gene-edited human cell lines. This project expects to generate new knowledge on how a family of evolutionary conserved proteins regulate autophagosome formation during starvation and stress conditions. Expected outcomes include the development of frontier imaging technologies that can be subsequently utilised for the advancement of any field of cell biology. This should provide significant benefits by placing Australia at the forefront of cell biology technologies and increasing our understanding of how plant and human cells can protect themselves during starvation and stress.

该项目旨在通过使用先进的多模式成像和独特的基因编辑的人类细胞系来研究自噬体如何在自噬过程中构建。该项目预计将产生关于一个进化保守蛋白家族如何在饥饿和应激条件下调节自噬体形成的新知识。预期成果包括开发前沿成像技术，随后可用于细胞生物学任何领域的发展。这将使澳大利亚处于细胞生物学技术的最前沿，并增加我们对植物和人类细胞如何在饥饿和压力下保护自己的理解，从而带来重大利益。