How cells control autophagy during nutrient starvation and stress

细胞如何在营养饥饿和应激期间控制自噬

• 批准号: FT160100063
• 负责人: A/Prof Michael Lazarou
• 金额: $ 46.44万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT160100063
• 关键词: How; cells; control; autophagy; during

This project aims to understand how human cells form autophagosomes during nutrient starvation and stress conditions, including bacterial invasion and mitochondrial dysfunction. Autophagy is a conserved intracellular degradation pathway which fungi, plants, insects and mammals use to respond to starvation and stress. Autophagy can provide nutrients by recycling cellular components, and protect cells from dysfunctional organelles and invading pathogens by mediating their removal. The autophagosome is a vesicular membrane structure important in autophagy by delivering material destined for degradation to the lysosome. Better understanding how plant and human cells protect themselves during starvation and stress is expected to benefit the environment and economy.

该项目旨在了解人类细胞如何在营养饥饿和压力条件下形成自噬体，包括细菌入侵和线粒体功能障碍。自噬是真菌、植物、昆虫和哺乳动物用来应对饥饿和应激的一种保守的细胞内降解途径。自噬可以通过回收细胞成分提供营养，并通过介导细胞器功能障碍和入侵病原体的清除来保护细胞免受它们的侵害。自噬体是一种泡状膜结构，通过将注定要降解的物质递送到溶酶体而在自噬中起重要作用。更好地了解植物和人类细胞如何在饥饿和压力下保护自己，有望有利于环境和经济。