A Cell-Based Analysis Platform to Screen Nutraceuticals and Functional Foods against Osteoporosis

基于细胞的分析平台，用于筛选抗骨质疏松症的营养保健品和功能性食品

• 批准号: 131470
• 金额: $ 10.47万
• 依托单位: AVANTICELL SCIENCE LIMITED
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=131470
• 关键词: Cell; Based; Analysis; Platform; Screen

The project will build a new tool for the identification of food constituents which can be used to prevent or treat osteoporosis. The new tools will be in the form of a cell culture system which contains human bone cells. These cells will be cultured under laboratory conditions in which they display activities relevant to the development of osteoporosis. These activities will be measured when the bone cells are exposed to new food materials, so that the system identifies those food constituents which may bring health benefit if incorporated into the diet. An important feature of the new test system will be the ability to apply mechanical stress to the bone cells, just as happens constantly in the body. This innovation will encourage bone cells to behave in culture as they do when inside the bone, and in doing so, should make food test results predict accurately their health benefit. In doing so, this new laboratory tool will reduce the need for animal testing of new foodstuffs, and make nutritional trials of functional foods more cost-effective, through early selection of candidates likely to give health-benefit, and de-selecting those destined to fail before major expense is incurred.

该项目将建立一种新的工具，用于识别可用于预防或治疗骨质疏松症的食物成分。新工具将以包含人骨细胞的细胞培养系统的形式出现。这些细胞将在实验室条件下培养，在实验室条件下它们表现出与骨质疏松症发展相关的活动。当骨骼细胞接触到新的食物材料时，将测量这些活动，以便系统识别如果将其纳入饮食中可能带来健康益处的食物成分。新测试系统的一个重要功能是能够对骨细胞施加机械应力，就像在人体内经常发生的那样。这项创新将鼓励骨细胞在培养中表现出它们在骨骼中的行为，这样做应该会使食品测试结果准确地预测它们对健康的好处。通过这样做，这个新的实验室工具将减少对新食品进行动物测试的需要，并使功能食品的营养试验更具成本效益，方法是及早选择可能对健康有益的候选者，并在发生重大费用之前取消那些注定失败的候选者的选择。