Non-animal replacement tests for acute toxicity testing

《化妆品条例》禁止在动物身上测试化妆品及其成分，以及禁止销售已在动物身上测试过的化妆品及其成分。该禁令于2013年3月11日全面生效，是数十年来获得巨大公众支持的运动的高潮。这一进展现在受到欧盟REACH法规的威胁，该法规仍然要求进行某些动物试验。这种监管冲突给英国/欧盟化妆品行业带来了巨大的困境，并使该行业的未来受到重大威胁。长期以来，动物试验一直是化妆品行业的一个高度情绪化的问题，也是一个主要的市场驱动力。REACH广泛支持动物试验的替代方案，但在目前没有有效替代方案的情况下，仍然需要动物试验。迫切需要既科学先进又符合伦理的非动物替代试验。项目合作伙伴将探索开发急性毒性相关试验的可行性，这些试验具有科学相关性，足够可靠和可重复，可（最终）作为经合组织试验指南采用。

The Cosmetics Regulation prohibits the testing of cosmetic products and their ingredients on animals, as well as the marketing of cosmetics and their ingredients that have been tested on animals for cosmetic purposes. The ban came into full effect on 11 March 2013 and was the culmination of several decades of campaigning with huge public support. This progress is now under threat by the EU REACH regulations, which still require certain animal tests to be performed. This regulatory clash presents the UK / EU cosmetics industry with an enormous dilemma and places the future of the industry under significant threat. Animal testing has long been a highly emotive issue in the cosmetics sector and a major market driver. REACH is broadly supportive of alternatives to animal testing, but still requires animal tests where there are currently no validated alternatives available. Non-animal replacement tests are urgently needed which are both scientifically advanced and ethically sound. The project partners will explore the feasibility of developing relacement tests for acute toxicity that are scientifically relevant and sufficiently robust and reproducible for (ultimate) adoption as OECD Test Guidelines.