HYPERGEN

超金

• 批准号: 2232860
• 负责人: ALBERT J OBERMAN
• 金额: $ 22.02万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-05 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2232860
• 关键词: HYPERGEN

From a combined base population of over 20,000 screened probands, a sample of 1,200 sibships have been indexed with 2 or more siblings having hypertension diagnosed before age 60. These sibships have been chosen to be equally divided into subgroups by race (black and non-black) and severity of hypertension (severe and mild) and can be further stratified by other pertinent factors (body mass index, plasma lipids, age of onset of hypertension, etc.). The choice of methods (genetic association and model-free sibship linkage) and large -sample size with ability to analyze within more homogeneous subgroups provide good power to detect specific genetic loci promoting hypertension despite considerable heterogeneity. Replication studies in independent populations (these subjects versus previously studied Utah sibships and versus other collaborative networks) will allow the confirmation of genetic loci for genes promoting hypertension. Loci found by other networks will also be rapidly tested in our subjects for confirmation. Epidemiologic analyses of persons with and without one or more confirmed genes for hypertension in combination with non-genetic factors and intermediate phenotypes will identify gene- environment interactions and specific lifestyle factors whose presence of absence seem to help determine the likelihood of expressing specific genetic predispositions to hypertension.

从超过20，000个筛选的先证者的组合基础人群中， 1,200个兄弟姐妹中有2个或更多兄弟姐妹 60岁以前诊断的高血压。这些兄弟姐妹被选中 按种族（黑人和非黑人）平均分为若干小组， 高血压的严重程度（重度和轻度），可进一步分层 其他相关因素（体重指数、血脂、发病年龄 高血压等）。方法的选择（遗传关联和 无模型亲缘关系）和大样本量，具有分析能力 在更同质的亚组中提供了良好的功效来检测特定的 遗传位点促进高血压，尽管有相当大的异质性。 在独立人群中进行的重复研究（这些受试者与 以前研究过犹他州的兄弟关系和其他合作网络） 将允许确认基因的遗传位点， 高血压其他网络发现的位置也将在 我们的实验对象进行确认流行病学分析的人与 没有一个或多个已证实的高血压基因， 非遗传因素和中间表型将识别基因- 环境相互作用和特定的生活方式因素， 缺席似乎有助于确定表达特定 高血压的遗传易感性