HYPERGEN
HYPERGEN
批准号:
6056301
负责人:
ALBERT J OBERMAN
金额:
$13.08万
依托单位国家:
美国
项目类别:
财政年份:
1995
资助国家:
美国
项目状态:
已结题
起止时间:
1995-09-05 至 2000-08-31
关键词:
African American alleles body physical characteristic caucasian American cooperative study disease /disorder classification disease /disorder proneness /risk epidemiology essential hypertension family genetics genetic polymorphism genome human genetic material tag human subject linkage mapping molecular genetics phenotype polymerase chain reaction
中文摘要
从超过20,000个筛选的先证者的组合基础人群中,
1,200个兄弟姐妹中有2个或更多兄弟姐妹
60岁以前诊断的高血压。这些兄弟姐妹被选中
按种族(黑人和非黑人)平均分为若干小组,
高血压的严重程度(重度和轻度),可进一步分层
其他相关因素(体重指数、血脂、发病年龄
高血压等)。方法的选择(遗传关联和
无模型亲缘关系)和大样本量,具有分析能力
在更同质的亚组中提供了良好的功效来检测特定的
遗传位点促进高血压,尽管有相当大的异质性。
在独立人群中进行的重复研究(这些受试者与
以前研究过犹他州的兄弟关系和其他合作网络)
将允许确认基因的遗传位点,
高血压其他网络发现的位置也将在
我们的实验对象进行确认流行病学分析的人与
没有一个或多个已证实的高血压基因,
非遗传因素和中间表型将识别基因-
环境相互作用和特定的生活方式因素,
缺席似乎有助于确定表达特定
高血压的遗传易感性
英文摘要
From a combined base population of over 20,000 screened probands, a sample
of 1,200 sibships have been indexed with 2 or more siblings having
hypertension diagnosed before age 60. These sibships have been chosen to
be equally divided into subgroups by race (black and non-black) and
severity of hypertension (severe and mild) and can be further stratified
by other pertinent factors (body mass index, plasma lipids, age of onset
of hypertension, etc.). The choice of methods (genetic association and
model-free sibship linkage) and large -sample size with ability to analyze
within more homogeneous subgroups provide good power to detect specific
genetic loci promoting hypertension despite considerable heterogeneity.
Replication studies in independent populations (these subjects versus
previously studied Utah sibships and versus other collaborative networks)
will allow the confirmation of genetic loci for genes promoting
hypertension. Loci found by other networks will also be rapidly tested in
our subjects for confirmation. Epidemiologic analyses of persons with and
without one or more confirmed genes for hypertension in combination with
non-genetic factors and intermediate phenotypes will identify gene-
environment interactions and specific lifestyle factors whose presence of
absence seem to help determine the likelihood of expressing specific
genetic predispositions to hypertension.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
HYPERGEN
-
批准号:2519498
-
项目类别:
-
资助金额:$41.04万
-
财政年份:1995
-
负责人:ALBERT J OBERMAN
-
依托单位:
HYPERGEN
-
批准号:2771432
-
项目类别:
-
资助金额:$39.01万
-
财政年份:1995
-
负责人:ALBERT J OBERMAN
-
依托单位:
HYPERGEN
-
批准号:2597955
-
项目类别:
-
资助金额:$0.63万
-
财政年份:1995
-
负责人:ALBERT J OBERMAN
-
依托单位:
HYPERGEN - BIRMINGHAM FIELD CENTER
-
批准号:6537193
-
项目类别:
-
资助金额:$9.46万
-
财政年份:1995
-
负责人:ALBERT J OBERMAN
-
依托单位:
HYPERGEN
-
批准号:2232860
-
项目类别:
-
资助金额:$22.02万
-
财政年份:1995
-
负责人:ALBERT J OBERMAN
-
依托单位:
HYPERGEN - BIRMINGHAM FIELD CENTER
-
批准号:6389484
-
项目类别:
-
资助金额:$33.78万
-
财政年份:1995
-
负责人:ALBERT J OBERMAN
-
依托单位:
HYPERGEN - BIRMINGHAM FIELD CENTER
-
批准号:6088987
-
项目类别:
-
资助金额:$30.92万
-
财政年份:1995
-
负责人:ALBERT J OBERMAN
-
依托单位:
HYPERGEN - BIRMINGHAM FIELD CENTER
-
批准号:6603934
-
项目类别:
-
资助金额:$0.0万
-
财政年份:1995
-
负责人:ALBERT J OBERMAN
-
依托单位:
HYPERGEN
-
批准号:2029435
-
项目类别:
-
资助金额:$36.68万
-
财政年份:1995
-
负责人:ALBERT J OBERMAN
-
依托单位:
CLINICAL CENTER FOR TRIALS OF HYPERTENSION PREVENTION
-
批准号:3552881
-
项目类别:
-
资助金额:$5.42万
-
财政年份:1990
-
负责人:ALBERT J OBERMAN
-
依托单位:
TRIALS OF HYPERTENSION PREVENTION (TOHP)--PHASE II
-
批准号:2218588
-
项目类别:
-
资助金额:$30.13万
-
财政年份:1986
-
负责人:ALBERT J OBERMAN
-
依托单位:
CARDIAC ADAPTATIONS--CORONARY HEART DISEASE
-
批准号:3353415
-
项目类别:
-
资助金额:$39.49万
-
财政年份:1986
-
负责人:ALBERT J OBERMAN
-
依托单位:
TRAINING LEVEL VS CARDIAC ADAPTATIONS IN PATIENTS W/CHD
-
批准号:3353416
-
项目类别:
-
资助金额:$33.87万
-
财政年份:1986
-
负责人:ALBERT J OBERMAN
-
依托单位:
TRIALS OF HYPERTENSION PREVENTION (TOHP) - PHASE II
-
批准号:3552885
-
项目类别:
-
资助金额:$59.97万
-
财政年份:1986
-
负责人:ALBERT J OBERMAN
-
依托单位:
TRIALS OF HYPERTENSION PREVENTION (TOHP) - PHASE II
-
批准号:3552880
-
项目类别:
-
资助金额:$38.71万
-
财政年份:1986
-
负责人:ALBERT J OBERMAN
-
依托单位:
CLINICAL CENTER FOR TRIALS OF HYPERTENSION PREVENTION
-
批准号:3552882
-
项目类别:
-
资助金额:$43.49万
-
财政年份:1986
-
负责人:ALBERT J OBERMAN
-
依托单位:
CLINICAL CENTER FOR TRIALS OF HYPERTENSION PREVENTION
-
批准号:3552883
-
项目类别:
-
资助金额:$36.29万
-
财政年份:1986
-
负责人:ALBERT J OBERMAN
-
依托单位:
TRAINING LEVEL VS. CARDIAC ADAPTATIONS--PATIENTS W/CHD
-
批准号:3353413
-
项目类别:
-
资助金额:$28.87万
-
财政年份:1986
-
负责人:ALBERT J OBERMAN
-
依托单位:
TRIALS OF HYPERTENSION PREVENTION (TOHP) - PHASE II
-
批准号:3552887
-
项目类别:
-
资助金额:$35.68万
-
财政年份:1986
-
负责人:ALBERT J OBERMAN
-
依托单位:
CLINICAL CENTER FOR TRIALS OF HYPERTENSION PREVENTION
-
批准号:3552884
-
项目类别:
-
资助金额:$38.49万
-
财政年份:1986
-
负责人:ALBERT J OBERMAN
-
依托单位:
海外基金