HYPERGEN

从20,000多名经过筛查的先证者的综合基础人口中， 已编制1,200个兄弟姐妹的索引，其中2个或更多兄弟姐妹具有 60岁以前确诊的高血压患者。这些兄弟会被选中是为了 按种族(黑人和非黑人)平均分为小组和 高血压的严重程度(重度和轻度)，并可以进一步分层 按其他相关因素(体重指数、血脂、发病年龄 高血压等)。方法的选择(遗传关联和 无模型兄弟关系链接)和具有分析能力的大样本量 在更同质的子组中提供了很好的能力来检测特定的 尽管存在相当大的异质性，但遗传基因座仍促进高血压。 独立人群中的复制研究(这些受试者与 之前研究了犹他州兄弟关系和与其他协作网络的对比) 将允许确认促进基因的遗传位点 高血压。其他网络发现的基因座也将在 我们的目标等待确认。艾滋病患者的流行病学分析 没有一个或多个确认的高血压基因合并 非遗传因素和中间表型将识别基因- 环境相互作用和特定的生活方式因素 缺席似乎有助于确定表达特定信息的可能性 高血压的遗传易感性。

From a combined base population of over 20,000 screened probands, a sample of 1,200 sibships have been indexed with 2 or more siblings having hypertension diagnosed before age 60. These sibships have been chosen to be equally divided into subgroups by race (black and non-black) and severity of hypertension (severe and mild) and can be further stratified by other pertinent factors (body mass index, plasma lipids, age of onset of hypertension, etc.). The choice of methods (genetic association and model-free sibship linkage) and large -sample size with ability to analyze within more homogeneous subgroups provide good power to detect specific genetic loci promoting hypertension despite considerable heterogeneity. Replication studies in independent populations (these subjects versus previously studied Utah sibships and versus other collaborative networks) will allow the confirmation of genetic loci for genes promoting hypertension. Loci found by other networks will also be rapidly tested in our subjects for confirmation. Epidemiologic analyses of persons with and without one or more confirmed genes for hypertension in combination with non-genetic factors and intermediate phenotypes will identify gene- environment interactions and specific lifestyle factors whose presence of absence seem to help determine the likelihood of expressing specific genetic predispositions to hypertension.