HYPERGEN

超金

• 批准号: 2519498
• 负责人: ALBERT J OBERMAN
• 金额: $ 41.04万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-05 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2519498
• 关键词: African American; alleles; body physical characteristic; caucasian American; cooperative study; disease /disorder classification; disease /disorder proneness /risk; epidemiology; essential hypertension; family genetics; genetic polymorphism; genome; human genetic material tag; human subject; linkage mapping; molecular genetics; phenotype; polymerase chain reaction

From a combined base population of over 20,000 screened probands, a sample of 1,200 sibships have been indexed with 2 or more siblings having hypertension diagnosed before age 60. These sibships have been chosen to be equally divided into subgroups by race (black and non-black) and severity of hypertension (severe and mild) and can be further stratified by other pertinent factors (body mass index, plasma lipids, age of onset of hypertension, etc.). The choice of methods (genetic association and model-free sibship linkage) and large -sample size with ability to analyze within more homogeneous subgroups provide good power to detect specific genetic loci promoting hypertension despite considerable heterogeneity. Replication studies in independent populations (these subjects versus previously studied Utah sibships and versus other collaborative networks) will allow the confirmation of genetic loci for genes promoting hypertension. Loci found by other networks will also be rapidly tested in our subjects for confirmation. Epidemiologic analyses of persons with and without one or more confirmed genes for hypertension in combination with non-genetic factors and intermediate phenotypes will identify gene- environment interactions and specific lifestyle factors whose presence of absence seem to help determine the likelihood of expressing specific genetic predispositions to hypertension.

从超过 20,000 名经过筛选的先证者的综合基础人群中，抽取了一个样本 1,200 个兄弟姐妹中的 2 个或更多兄弟姐妹已被索引 60 岁之前诊断出高血压。这些同胞已被选择 按种族（黑人和非黑人）平均分为亚组，并且 高血压的严重程度（重度和轻度）并且可以进一步分层 其他相关因素（体重指数、血脂、发病年龄 高血压等）。方法的选择（遗传关联和 无模型同胞关系）和大样本量，具有分析能力 在更同质的子组中提供了良好的能力来检测特定的 尽管存在相当大的异质性，但促进高血压的遗传位点。 独立人群中的复制研究（这些受试者与 之前研究过犹他州同胞关系以及与其他协作网络的比较） 将允许确认促进基因的遗传位点 高血压。其他网络发现的基因座也将在快速测试中 我们的确认主题。患有以下疾病的人的流行病学分析 没有一种或多种已证实的高血压基因与 非遗传因素和中间表型将识别基因 环境相互作用和特定生活方式因素的存在 缺席似乎有助于确定表达特定内容的可能性 高血压的遗传倾向。